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Single Nucleotide Polymorphism in the ADIPOQ Gene Modifies Adiponectin Levels and Glycemic Control in Type Two
Mahmoud A Alfaqih1, Aisha Al-Hawamdeh1, Zouhair O Amarin2
1Department of Physiology and Biochemistry, Faculty of Medicine, Jordan University of Science and Technology, Irbid 22110, Jordan.
Biomed Research International
|May 9, 2022
Summary
Genetic variations in the ADIPOQ gene, specifically the rs2241766 SNP, are linked to lower adiponectin levels and poorer glycemic control in type 2 diabetes patients.
Area of Science:
- Genetics
- Endocrinology
- Metabolic Diseases
Background:
- Diabetes mellitus (DM) is a leading cause of death, with complications often stemming from poor glycemic control.
- Genetic factors, including single nucleotide polymorphisms (SNPs), may influence glycemic control in DM patients.
- Adiponectin, a hormone involved in glucose and lipid metabolism, shows dysregulated levels in DM patients with poor glycemic control.
Purpose of the Study:
- To investigate the hypothesis that SNPs in the ADIPOQ gene modify glycemic control in type 2 DM (T2DM) patients.
- To determine the association between ADIPOQ gene variations, serum adiponectin levels, and glycemic control in T2DM.
Main Methods:
- Recruited 375 T2DM patients, classifying them by glycemic control (good vs. poor) based on hemoglobin A1c levels.
- Genotyped four ADIPOQ SNPs (rs17300539, rs266729, rs2241766, rs1501299) and measured serum adiponectin levels.
- Utilized statistical analysis to identify predictors of poor glycemic control and associations with genotypes and adiponectin levels.
Main Results:
- Reduced serum adiponectin, longer treatment duration, and increased insulin resistance were significant predictors of poor glycemic control.
- The T allele and TT genotype of ADIPOQ SNP rs2241766 were more frequent in patients with poor glycemic control (P < 0.05).
- Individuals with the rs2241766 TT genotype exhibited significantly lower serum adiponectin levels (P < 0.05).
Conclusions:
- Lower serum adiponectin levels are associated with poor glycemic control in T2DM patients.
- The T allele of the ADIPOQ rs2241766 SNP is linked to poor glycemic control and reduced adiponectin levels in T2DM.
- ADIPOQ gene variations represent a potential genetic factor influencing glycemic control in type 2 diabetes.
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