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Microfluidic Chip Fabrication and Method to Detect Influenza
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3D-Printed SARS-CoV-2 RNA Genosensing Microfluidic System.

Agustín G Crevillen1,2, Carmen C Mayorga-Martinez1, Jayraj V Vaghasiya1

  • 1Center for Advanced Functional Nanorobots Department of Inorganic Chemistry University of Chemistry and Technology Prague Technicka 5 Prague 6 166 28 Czech Republic.

Advanced Materials Technologies
|May 11, 2022
PubMed
Summary
This summary is machine-generated.

A 3D-printed electrochemical genosensor offers rapid and sensitive detection of SARS-CoV-2. This lab-on-a-chip device utilizes a 3D printing pen for fabrication, enabling quick screening during pandemics.

Keywords:
additive manufacturingelectroanalysislab on chipnucleic acid

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Area of Science:

  • Biomedical Engineering
  • Materials Science
  • Analytical Chemistry

Background:

  • Additive manufacturing, or 3D printing, is a versatile technology with applications ranging from nanosensors to construction.
  • The COVID-19 pandemic necessitates simple and rapid diagnostic systems.
  • Lab-on-a-chip devices combined with electrochemical detection offer a promising approach for fast screening.

Purpose of the Study:

  • To develop a 3D-printed electrochemical genosensor for rapid and sensitive detection of SARS-CoV-2.
  • To integrate a 3D printing pen (3D-PP) fabricated electrochemical cell with a PDMS microfluidic channel.
  • To demonstrate the feasibility of using this system for pandemic-related diagnostics.

Main Methods:

  • Fabrication of a microfluidic channel using PDMS.
  • 3D printing of an electrochemical cell using a 3D printing pen (3D-PP).
  • Modification of the genosensor with an ssDNA probe targeting the SARS-CoV-2 N gene.
  • Electrochemical detection based on the electro-oxidation of adenine in ssDNA.

Main Results:

  • The 3D-PP genosensor demonstrated high sensitivity for SARS-CoV-2 detection.
  • The system exhibited a fast response time for screening.
  • The sensing mechanism involves a decrease in sensor signal upon hybridization due to ssDNA desorption.

Conclusions:

  • The developed 3D-printed genosensor is a viable tool for rapid SARS-CoV-2 detection.
  • This technology offers a simple and effective solution for pandemic screening.
  • 3D printing technology enables accessible fabrication of diagnostic devices.