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Motor neuron disease: epidemiologic studies.

D W Mulder, L T Kurland

    Advances in Experimental Medicine and Biology
    |January 1, 1987
    PubMed
    Summary
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    The cause of motor neuron disease (MND) remains unknown, and current treatments only support patients. This review examines epidemiologic studies to find patterns that may reveal MND

    Area of Science:

    • Neurology
    • Epidemiology
    • Public Health

    Background:

    • Motor neuron disease (MND) etiology is unknown.
    • Current treatments for MND are limited to supportive care.

    Purpose of the Study:

    • To review epidemiologic studies for patterns in MND clinical expression.
    • To identify potential etiologic hypotheses for MND based on occurrence patterns and disease analogies.

    Main Methods:

    • Systematic review of selected epidemiologic studies on MND.
    • Analysis of patterns in MND occurrence and clinical presentation.
    • Comparison of MND with diseases of known etiology.

    Main Results:

    • Identified patterns in the clinical expression of MND.

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  • Recognized potential associations between MND and other diseases.
  • Highlighted analogies with known disease mechanisms.

    • Conclusions:

    • Recognizing occurrence patterns may form the basis for testable MND etiologic hypotheses.
    • Associations and analogies with known diseases can generate further etiologic hypotheses for MND.