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Assessing Early Stage Open-Angle Glaucoma in Patients by Isolated-Check Visual Evoked Potential
Published on: May 25, 2020
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Alterations in Fixation Indices in Primary Open-Angle Glaucoma by Microperimetry.
Katarzyna Zabel1, Przemyslaw Zabel1, Karolina Suwala1
1Department of Sensory Organ Studies, Collegium Medicum, Nicolaus Copernicus University, 85-830 Bydgoszcz, Poland.
Journal of Clinical Medicine
|May 14, 2022
Summary
Primary open-angle glaucoma (POAG) worsens fixation stability as the disease progresses. Microperimetry (MP) effectively detects these changes, correlating with other retinal structure and function indicators.
Area of Science:
- Ophthalmology
- Neuroscience
Background:
- Primary open-angle glaucoma (POAG) is a leading cause of irreversible blindness.
- Understanding the functional and structural changes associated with POAG progression is crucial for early detection and management.
Purpose of the Study:
- To investigate the association between primary open-angle glaucoma (POAG) and changes in fixation stability parameters.
- To determine if glaucoma severity correlates with a decline in fixation stability indicators.
- To explore the relationship between fixation stability and other retinal structure and function metrics.
Main Methods:
- Microperimetry (MP) macular analyzer integrity assessment (MAIA) was used to evaluate fixation stability in patients with mild and moderate/severe POAG, and healthy controls.
- Fixation indices were correlated with MP, standard automated perimetry (SAP), optical coherence tomography (OCT), and OCT angiography (OCTA) parameters.
- 54 eyes with POAG (32 mild, 22 moderate/severe) and 24 healthy eyes were analyzed.
Main Results:
- Fixation stability deteriorated with increasing POAG severity.
- Significant differences in bivariate contour ellipse area (BCEA) were observed among the groups (p = 0.042).
- Retinal structure and function parameters also showed significant deterioration with glaucoma progression (p < 0.001), with confirmed correlations to fixation parameters.
Conclusions:
- Primary open-angle glaucoma (POAG) is linked to disturbances in the fixation pattern.
- These fixation disturbances worsen as the disease progresses.
- Microperimetry (MP) is an effective tool for assessing these changes in POAG patients.
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