Related Experiment Video
Updated: Sep 23, 2025
07:47
Transplantation of a 3D Bioprinted Patch in a Murine Model of Myocardial Infarction
Published on: September 26, 2020
6.7K
Advances in three-dimensional bioprinted stem cell-based tissue engineering for cardiovascular regeneration
Astha Khanna1, Bugra Ayan2, Ada A Undieh3
1Graver Technologies, Newark, NJ 07105, USA.
Journal of Molecular and Cellular Cardiology
|May 15, 2022
Summary
Three-dimensional bioprinting advances tissue engineering for cardiovascular applications. Challenges remain in replicating native tissue complexity and vascularization for clinical translation.
Area of Science:
- Biotechnology
- Regenerative Medicine
- Tissue Engineering
Background:
- Three-dimensional (3D) bioprinting aims to replicate cardiovascular tissue characteristics.
- Current limitations include extracellular matrix complexity and cellular function recapitulation.
- Incorporating vascular networks is crucial for nutrient and oxygen perfusion in engineered tissues.
Purpose of the Study:
- To review novel 3D bioprinting techniques and materials for cardiovascular tissue engineering.
- To highlight the current state of engineered cardiovascular tissue models.
- To discuss applications and challenges in translating 3D bioprinted constructs for clinical use.
Main Methods:
- Review of emerging 3D bioprinting technologies.
- Analysis of bioinks and printing materials used in cardiovascular applications.
- Examination of current engineered cardiovascular tissue models.
Main Results:
- Summarized new generation 3D bioprinting techniques and materials.
- Highlighted state-of-the-art engineered cardiovascular tissue models.
- Discussed applications in myocardium, cardiac valves, and vascular grafts.
Conclusions:
- 3D bioprinting offers potential for cardiovascular tissue regeneration.
- Key challenges include achieving native vasculature, architecture, and functionality.
- Further research is needed for successful clinical translation.
