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Related Concept Videos

Atherosclerosis I: Introduction01:30

Atherosclerosis I: Introduction

107
Atherosclerosis is a progressive disorder characterized by the buildup of plaques on the arterial inner wall, causing them to narrow and harden over time. These plaques comprise lipids, calcium, blood components, carbohydrates, and fibrous tissue. The process primarily affects the intima of large and medium-sized arteries, reducing blood flow in any artery.Etiology and risk factorsThe cause of atherosclerosis is multifactorial, involving a complex interplay among endothelial injury, lipid...
107
Atherosclerosis III: Management01:26

Atherosclerosis III: Management

48
Management of atherosclerosis involves an integrated strategy encompassing pharmacological treatment, surgical interventions, lifestyle changes, and nutrition therapy to address the multifactorial nature of the disease.Pharmacological TherapyA cornerstone of atherosclerosis management is the use of pharmacological agents. Statins, such as atorvastatin, are pivotal in inhibiting HMG-CoA reductase, an enzyme that catalyzes an initial step in cholesterol synthesis in the liver. This reduction in...
48
Coronary Artery Disease I: Introduction01:30

Coronary Artery Disease I: Introduction

74
Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
74
Coronary Artery Disease II: Pathophysiology01:26

Coronary Artery Disease II: Pathophysiology

50
Coronary Artery Disease (CAD) originates from a series of events that impair the function of coronary arteries, the blood vessels responsible for delivering oxygen-rich blood to the heart muscle. The pathophysiology of CAD is closely linked to atherosclerosis, a chronic inflammatory and lipid-driven condition affecting the vascular endothelium.1. Endothelial DamageThe process begins with damage to the vascular endothelium, which serves as a protective barrier between the blood and the vessel...
50
Coronary Artery Disease IV: Preventive Measures01:26

Coronary Artery Disease IV: Preventive Measures

44
Effective preventive measures for coronary artery disease (CAD) focus on controlling modifiable risk factors, including cholesterol abnormalities and lifestyle changes.Cholesterol ManagementFirst, the Mediterranean diet and the American Heart Association advocate for maintaining low-density lipoprotein (LDL) cholesterol levels below 100 mg/dL, with a more stringent recommendation of below 70 mg/dL for individuals at high risk. LDL cholesterol, often termed "bad cholesterol," can lead to the...
44
Cholesterol: Significance and Regulation01:29

Cholesterol: Significance and Regulation

709
Although not a source of energy, cholesterol plays a significant role as a foundational structure for bile salts, steroid hormones, and vitamin D, as well as being a crucial component of plasma membranes. Approximately 15% of blood cholesterol is derived from our diet, with the remainder synthesized from acetyl CoA by the liver and intestines. Cholesterol is eliminated from the body through its conversion into bile salts, which are eventually discarded in the feces.
Considering cholesterol and...
709

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Related Experiment Video

Updated: Sep 23, 2025

Cell-free Biochemical Fluorometric Enzymatic Assay for High-throughput Measurement of Lipid Peroxidation in High Density Lipoprotein
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Cell-free Biochemical Fluorometric Enzymatic Assay for High-throughput Measurement of Lipid Peroxidation in High Density Lipoprotein

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HDL and ASCVD.

Hongtu Cui1, Qian Du2

  • 1Department of Cardiology and Institute of Vascular Medicine, Peking University Third Hospital, NHC Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides, Key Laboratory of Molecular Cardiovascular Science, Ministry of Education, Beijing Key Laboratory of Cardiovascular Receptors Research, Beijing, China.

Advances in Experimental Medicine and Biology
|May 16, 2022
PubMed
Summary
This summary is machine-generated.

High-density lipoprotein (HDL) plays a key role in atherosclerotic cardiovascular disease (ASCVD). New HDL-based therapies are emerging to combat this condition.

Keywords:
Atherosclerotic cardiovascular disease (ASCVD)High-density lipoprotein (HDL)Molecular mechanism

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Area of Science:

  • Cardiovascular Science
  • Lipid Metabolism
  • Immunology

Background:

  • Atherosclerotic cardiovascular disease (ASCVD) remains a leading cause of mortality worldwide.
  • High-density lipoprotein (HDL) is a critical lipoprotein involved in reverse cholesterol transport.
  • Dysfunctional HDL is implicated in the pathogenesis of ASCVD.

Purpose of the Study:

  • To elucidate the multifaceted relationship between circulating HDL and ASCVD.
  • To explore the cellular actions of HDL in key cell types relevant to atherogenesis.
  • To review recent advancements in HDL-targeting therapies for ASCVD.

Main Methods:

  • Literature review and synthesis of existing research on HDL and ASCVD.
  • Analysis of studies investigating HDL's cellular interactions (endothelial cells, macrophages, T lymphocytes).
  • Overview of novel therapeutic strategies modulating HDL function or levels.

Main Results:

  • HDL exhibits protective effects against ASCVD through various mechanisms.
  • HDL interacts with diverse cell types, influencing inflammatory and metabolic processes within the arterial wall.
  • Emerging therapies aim to enhance HDL's atheroprotective functions.

Conclusions:

  • The intricate relationship between HDL and ASCVD underscores HDL's therapeutic potential.
  • Targeting HDL offers a promising avenue for novel ASCVD treatments.
  • Further research into HDL's cellular roles will refine therapeutic strategies.