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Updated: Sep 22, 2025

Synthesis of Hypervalent Iodonium Alkynyl Triflates for the Application of Generating Cyanocarbenes
Published on: September 8, 2013
Transition Metal-Free Iodine-Catalyzed Denitrative C-S Cross-Coupling: An Atypical Route to Access Thiochromane
Anuradha Nandy1, Govindasamy Sekar1
1Department of Chemistry, Indian Institute of Technology Madras, Chennai600 036, Tamil Nadu, India.
Abstract:
An iodine-catalyzed denitrative C-S cross-coupling reaction has been developed to attain thiochromanones from 2'-nitrochalcones and xanthate. The strategy was extended for a three-component synthesis of thiochromenes via intermolecular C-S cross-coupling followed by aldol reaction. The reaction proceeds via activation of the keto group of chalcone through a halogen bond complex with iodine/denitrative C-S bond formation with xanthate/sulfa-Michael addition to chalcones. The methodology was also demonstrated for chemoselective reduction of chalcones. The protocol was also employed to synthesize biologically important 3'-hydroxythioflavone and thiochromenones.
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