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Multicharged cyclodextrin supramolecular assemblies.

Zhixue Liu1, Yu Liu1,2

  • 1State Key Laboratory of Elemento-Organic Chemistry, College of Chemistry, Nankai University, Tianjin 300071, P. R. China. yuliu@nankai.edu.cn.

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|May 20, 2022
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Summary
This summary is machine-generated.

Multicharged cyclodextrins (CDs) and their supramolecular assemblies offer enhanced antiviral, antibacterial, and antifibrosis properties. These charged CDs effectively encapsulate various molecules, improving drug delivery and material properties.

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Area of Science:

  • Supramolecular Chemistry
  • Materials Science
  • Biomedical Science

Background:

  • Cyclodextrins (CDs) are widely used in various scientific fields.
  • Charged CDs and their supramolecular assemblies are gaining attention for specialized applications.
  • Understanding the construction and properties of charged CD assemblies is crucial.

Purpose of the Study:

  • To review recent advances in charged cyclodextrins (CDs) and parent CDs encapsulating charged guests.
  • To summarize the construction processes of these supramolecular assemblies.
  • To highlight their diverse applications and advantages over uncharged CDs.

Main Methods:

  • Review of recent literature on charged cyclodextrin supramolecular assemblies.
  • Analysis of construction strategies for these assemblies.
  • Examination of applications in various scientific disciplines.

Main Results:

  • Multicharged CDs exhibit superior antiviral, antibacterial, and protein fibrosis inhibition compared to uncharged CDs.
  • Charged CDs effectively interact with oppositely charged molecules (dyes, drugs, polymers, biomacromolecules) for encapsulation and aggregation.
  • Supramolecular assemblies of charged CDs enhance drug delivery, material luminescence, molecular recognition, imaging, and hydrogel properties.

Conclusions:

  • Multicharged CD supramolecular assemblies offer significant advantages in various applications.
  • These assemblies demonstrate potential for developing advanced materials and therapeutic strategies.
  • Further exploitation of charged CD assemblies is expected to drive innovation in supramolecular chemistry and interdisciplinary fields.