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Herpesviruses in Periodontitis: An Umbrella Review
Aleksandar Jakovljevic1, Miroslav Andric2, Jelena Jacimovic3
1Department of Pathophysiology, School of Dental Medicine, University of Belgrade, Belgrade, Serbia. dr.sasuli@hotmail.com.
Advances in Experimental Medicine and Biology
|May 25, 2022
Summary
Herpesviruses may increase the risk of marginal periodontitis (MP), but evidence is uncertain due to low-quality studies. No significant association was found with apical periodontitis of endodontic origin (APEO).
Area of Science:
- Oral microbiology
- Periodontology
- Infectious diseases
Background:
- Herpesviruses are frequently detected in periodontal disease samples.
- Their precise role in the pathogenesis of periodontitis remains unclear.
Purpose of the Study:
- To conduct an umbrella review of systematic reviews on herpesvirus detection in marginal periodontitis (MP) and apical periodontitis of endodontic origin (APEO).
Main Methods:
- Systematic search of multiple databases (Web of Science, Scopus, PubMed, Cochrane) up to October 2020.
- Inclusion of systematic reviews (with or without meta-analysis) assessing herpesviruses and periodontal diseases.
- Quality assessment of included reviews using AMSTAR 2 tool.
Main Results:
- Six systematic reviews were included; four were critically low-quality.
- Herpesviruses in subgingival samples showed an association with increased MP risk (OR > 3.0), but with wide confidence intervals and significant heterogeneity.
- Publication bias was detected; no significant association was found for APEO.
Conclusions:
- Low-quality evidence suggests a potential link between herpesviruses and MP.
- This association is uncertain due to study limitations and high heterogeneity.
- No significant association was identified between herpesviruses and APEO.
