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An Aptamer-based Sensor for Unchelated GadoliniumIII
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Gadolinium-Based Contrast Agents: Updates and Answers to Typical Questions Regarding Gadolinium Use.
Benjamin Y C Cheong1,2, James M Wilson3, Ourania A Preventza4,5
1Department of Cardiology, Texas Heart Institute, Houston, Texas.
Texas Heart Institute Journal
|May 25, 2022
Summary
Gadolinium-based contrast agents enhance MRI scans but can cause nephrogenic systemic fibrosis in patients with kidney disease. Recent findings show gadolinium deposition in the brain, even with normal kidney function.
Area of Science:
- Radiology
- Nephrology
- Neurology
Background:
- Gadolinium-based contrast agents (GBCAs) are vital for magnetic resonance imaging (MRI) diagnostics.
- While generally safe, GBCAs have been linked to nephrogenic systemic fibrosis (NSF) in patients with severe kidney disease.
- Emerging research indicates gadolinium deposition in the brain and other organs following GBCA administration, irrespective of renal function.
Purpose of the Study:
- To review recent advancements concerning gadolinium-based contrast agents.
- To discuss clinical scenarios involving the use of GBCAs.
- To address emerging concerns regarding gadolinium deposition.
Main Methods:
- Literature review of recent studies on GBCAs.
- Analysis of clinical case reports and observational studies.
- Synthesis of current understanding of GBCA safety and deposition.
Main Results:
- GBCAs significantly improve MRI diagnostic capabilities.
- NSF is a rare but serious complication associated with GBCAs in advanced kidney disease.
- Trace amounts of gadolinium have been detected in the brain and other organs post-contrast administration, even in individuals with normal renal function.
Conclusions:
- GBCAs remain essential tools in diagnostic imaging.
- Awareness of potential risks, including NSF and gadolinium deposition, is crucial.
- Further research is needed to fully understand the long-term implications of gadolinium deposition.
Keywords:
Acute kidney injury/complicationsgadolinium/administration & dosage/adverse effectsimage enhancement/methodskidney failure, chronic/complicationskidney/diagnostic imagingmagnetic resonance imagingnephrogenic fibrosing dermopathy/chemically induced/prevention & controlpractice guidelines as topicrenal dialysisrisk factorsMore Related Videos
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