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Investigating the epidemiological relationship between vitiligo and psoriasis: a population-based study
Khalaf Kridin1,2,3, Keren Lyakhovitsky4, Erez Onn5
1Unit of Dermatology and Skin Research Laboratory, Baruch Padeh Poria Medical Center, M.P. The lower Galilee, 15208, Poriya, Israel. dr_kridin@hotmail.com.
Archives of Dermatological Research
|May 25, 2022
Summary
Vitiligo diagnosis increases the risk of developing psoriasis. While psoriasis slightly increases vitiligo risk, the link is less pronounced. This comorbidity warrants clinical attention.
Area of Science:
- Dermatology
- Epidemiology
- Autoimmune Diseases
Background:
- The relationship between vitiligo and psoriasis lacks consistent evidence in scientific literature.
- Understanding the bidirectional association is crucial for clinical practice.
Purpose of the Study:
- To investigate the potential link between vitiligo and psoriasis.
- To assess if vitiligo increases psoriasis risk and vice versa.
Main Methods:
- A large population-based study compared 20,851 vitiligo patients with 102,475 controls.
- Cox and logistic regression models were used to calculate adjusted hazard ratios (HRs) and odds ratios (ORs).
Main Results:
- Vitiligo patients had a significantly higher incidence of new-onset psoriasis (HR 1.71).
- Patients with psoriasis showed a marginally increased odds of vitiligo (OR 1.19).
- Vitiligo patients with psoriasis were older at onset and had more comorbidities.
Conclusions:
- Vitiligo is a risk factor for developing psoriasis.
- Clinicians should consider this comorbidity in dermatologic patient management.
- Further research is needed to understand the underlying mechanisms.
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