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Updated: Sep 21, 2025

Granulocyte-dependent Autoantibody-induced Skin Blistering
Published on: October 12, 2012
Pediatric Autoimmune Bullous Disease: A Literature Review and Update on Management
Rosalind Ashton1, Hiva Fassihi2
1University of Ottawa, Ottawa, ON, Canada.
Abstract:
Pediatric autoimmune bullous disease is a rare group of blistering skin disorders in children that result from autoimmunity against intercellular and basement membrane antigens in the skin and mucous membranes. Most pediatric cases are treated with oral corticosteroids or longer-term immunosuppressants such as azathioprine or mycophenolate mofetil. Immunomodulating drugs such as rituximab are increasingly being considered as options for refractory disease.
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