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Neglected N-Truncated Amyloid-β Peptide and Its Mixed Cu-Zn Complexes

Tomasz Frączyk1, Piotr Cieplak2

  • 1Institute of Biochemistry and Biophysics, Polish Academy of Sciences, Pawińskiego 5a Street, 02-106, Warsaw, Poland. tfraczyk@ibb.waw.pl.

The Protein Journal
|June 1, 2022
PubMed
Summary

Investigating copper and zinc interactions with N-truncated amyloid-beta (Aβ) peptides in Alzheimer's disease (AD) reveals two distinct complexes. One complex may offer neuroprotection, while another could promote toxic oligomer formation, suggesting new AD research avenues.

Keywords:
Alzheimer’s diseaseAmyloid-βCopper complexMixed complexZinc complex

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