Refractory angiolymphoid hyperplasia with eosinophilia: Complete resolution with low dose thalidomide

Area of Science:

• Dermatology
• Vascular Biology
• Oncology

Background:

• Angiolymphoid hyperplasia with eosinophilia (ALHE) is a rare, benign vascular proliferation.
• ALHE typically presents as papules or nodules on the head and neck, often the ear.
• It is characterized by a difficult-to-treat nature and potential resistance to standard therapies.

Observation:

• A case of ALHE presented with persistent lesions despite multiple treatment attempts.
• Previous interventions for this ALHE case proved ineffective.
• The patient's lesions were resistant to various therapeutic strategies.

Findings:

• Complete resolution of ALHE was achieved using thalidomide.
• Thalidomide demonstrated significant efficacy in a treatment-resistant ALHE case.
• This finding highlights thalidomide as a potential therapeutic option for refractory ALHE.

Implications:

• Thalidomide may offer a novel treatment avenue for refractory angiolymphoid hyperplasia with eosinophilia.
• This case suggests a potential role for immunomodulatory agents in managing ALHE.
• Further research into thalidomide's mechanism in ALHE is warranted for clinical application.