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Related Concept Videos

Drug Delivery: Miscellaneous Routes01:22

Drug Delivery: Miscellaneous Routes

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Drug delivery methods like oral inhalation, nasal sprays, transdermal patches, eye drops, intravitreal injection,  and rectal administration provide localized effects with reduced toxicity.
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs...
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Drug Delivery: Overview01:16

Drug Delivery: Overview

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The selection of a drug's delivery route depends upon its physicochemical properties, including lipid or water solubility and ionization, as well as the therapeutic requirement, such as immediate or sustained effect. These routes can be divided into three primary categories: enteral, parenteral, and topical.
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the...
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Drug Delivery: Enteral Route01:18

Drug Delivery: Enteral Route

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The enteral drug administration involves three primary routes: oral, sublingual, and buccal. Oral ingestion is the most prevalent, safe, economical, and convenient method for drug administration. However, it has certain drawbacks, including limited absorption due to the drug's low water solubility or poor membrane permeability, possible emesis from GI mucosa irritation, destruction of drugs by digestive enzymes or low gastric pH, and irregular absorption along with food or other drugs.
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Drug Delivery: Parenteral Route01:29

Drug Delivery: Parenteral Route

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The parenteral route is a critical method of drug administration. It delivers compounds directly into the systemic circulation and bypasses the gastrointestinal tract. This approach is particularly advantageous for drugs that exhibit poor absorption or instability when administered orally.
There are three primary parenteral routes: intravenous (IV), intramuscular (IM), and subcutaneous (SC). The IV route introduces the drug directly into the bloodstream, ensuring immediate action. The IM route...
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Direct-Acting Cholinergic Agonists: Pharmacokinetics01:31

Direct-Acting Cholinergic Agonists: Pharmacokinetics

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Direct-acting cholinergic agonists, such as synthetic choline esters and naturally occurring alkaloids, exert their effects by enhancing the actions of acetylcholine and stimulating the parasympathetic nervous system. Synthetic choline esters share structural similarities with acetylcholine. For example, they have a positively charged quaternary ammonium or onium group, contributing to their hydrophilic characteristics. As a result, they are poorly absorbed in the body through oral...
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Drug Biotransformation: Overview01:16

Drug Biotransformation: Overview

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Pharmaceutical substances known as xenobiotics are predominantly lipophilic and nonionized. This enables them to permeate lipid bilayers, such as cell membranes, and interact with intracellular target receptors. Lipophilic drugs have an advantage in crossing biological barriers and reaching their intended sites of action. However, lipophilic drugs often have a restricted capacity for renal expulsion or elimination from the body. When these drugs enter the kidneys and undergo glomerular...
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Updated: Sep 8, 2025

Author Spotlight: Eco-friendly Photoluminescent Textile Authentication with Curcumin
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Recent updates in curcumin delivery.

Mohammad A Obeid1, Manal Alsaadi2, Alaa A Aljabali1

  • 1Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, Yarmouk University, Irbid, Jordan.

Journal of Liposome Research
|June 14, 2022
PubMed
Summary
This summary is machine-generated.

Curcumin, a natural compound from turmeric, has therapeutic potential but faces bioavailability challenges. Nanoparticles (NPs) like liposomes and niosomes enhance curcumin delivery and solubility for improved clinical applications.

Keywords:
Curcuminclinical trialdrug deliveryliposomesniosomes nanoparticle

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Area of Science:

  • Natural Product Chemistry
  • Nanotechnology
  • Pharmacology

Background:

  • Curcumin, derived from turmeric (Curcuma longa), possesses significant antioxidant and anti-inflammatory properties.
  • Historically used for over 4000 years, curcumin shows therapeutic promise for arthritis, liver diseases, neurodegenerative disorders, obesity, and cancer.
  • Clinical use of curcumin is limited by poor water solubility, low bioavailability, rapid metabolism, and chemical instability.

Purpose of the Study:

  • To review various nanoparticle (NP) systems developed to overcome curcumin's limitations.
  • To analyze recent studies on the efficacy of different NPs in enhancing curcumin solubility and bioavailability.
  • To highlight advancements in site-specific drug delivery using nanomaterials for curcumin.

Main Methods:

  • Literature review of electronic databases (PubMed, Google Scholar, Scopus).
  • Keywords used: lipid-based nanoparticles, curcumin delivery, niosomes, liposomes.
  • Focus on recent studies investigating nanoparticle-mediated curcumin delivery.

Main Results:

  • Nanotechnology offers solutions to curcumin's poor solubility and bioavailability issues.
  • Various NPs, including liposomes and niosomes, have been successfully employed to improve curcumin's absorption and stability.
  • Recent studies demonstrate enhanced therapeutic outcomes with NP-formulated curcumin.

Conclusions:

  • Nanoparticle-based delivery systems are crucial for overcoming curcumin's pharmacokinetic limitations.
  • Liposomes, niosomes, and other NPs significantly improve curcumin's solubility, bioavailability, and stability.
  • Further research into NP-curcumin formulations holds promise for expanded clinical applications.