Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Zygotic Development And Stem Cell Formation01:10

Zygotic Development And Stem Cell Formation

5.5K
The development of all multicellular organisms starts with the fusion of haploid cells called sperm and egg to form a diploid zygote. A zygote is a totipotent cell that can develop into a complete organism. The zygote undergoes cell division or cleavage to form an 8-cell mass. Until this stage, the cells are spherical, loosely attached, and remain totipotent. Totipotent cells are capable of developing both the embryonic and the extraembryonic tissues. However, as they continue to divide, they...
5.5K
Cell Diversity01:13

Cell Diversity

3.8K
The concept of a cell started with microscopic observations of dead cork tissue by Robert Hooke in 1665. Hooke coined the term "cell" based on the resemblance of the small subdivisions in the cork to the rooms that monks inhabited, called cells. About ten years later, Antonie van Leeuwenhoek became the first person to observe the living and moving cells under a microscope. In the century that followed, the theory that cells represented the basic unit of life developed.
Multicellular...
3.8K
Renewal of Intestinal Stem Cells01:23

Renewal of Intestinal Stem Cells

2.7K
The intestinal epithelial lining rapidly renews every 4 to 5 days. The renewal is facilitated by intestinal stem cells (ISCs) located at the base of the crypt– a gland located at the bottom of each villus. ISCs divide asymmetrically to form new stem cells and progenitor daughter cells. The daughter cells are called transit-amplifying (TA) cells which move upwards along the crypt and either differentiate into absorptive cells– the enterocytes or secretory cells– including the...
2.7K
Cell Motility through Blebbing01:16

Cell Motility through Blebbing

2.0K
Blebs are a type of membrane protrusion formed by the internal hydrostatic pressure of the cytoplasm. Blebs are observed in several cell types, including fibroblasts, immune cells, and single-celled organisms like the amoeba. The primary function of blebs is cell locomotion and apoptosis, but they are also found during necrosis and cell division. The life cycle of a bleb comprises an initiation phase followed by the expansion and retraction phases.
Blebbing Through the Matrix
In multicellular...
2.0K
Cell Migration01:09

Cell Migration

17.2K
Cell migration, the process by which cells move from one location to another, is essential for the proper development and viability of organisms throughout their life. When cells are not able to migrate properly to their ordained locations, various disorders may occur. For example, disruption in cell migration causes chronic inflammatory diseases such as arthritis.
17.2K
Exocrine Glands: Unicellular and Multicellular Glands01:29

Exocrine Glands: Unicellular and Multicellular Glands

17.5K
Exocrine glands are classified as unicellular and multicellular. The unicellular glands are scattered single cells, such as goblet cells, found in the mucous membranes of the small and large intestines. On the other hand, multicellular exocrine glands develop as secretory sheets, like the internal lining of the abdomen or chest. Such secretory sheets release their secretions directly into the lumen of these organs. In addition, some multicellular glands have deep-seated secretory units to...
17.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A Switch in Iron Delivery Is Critical for Postnatal Kidney Development.

Kidney360·2026
Same author

Automated Ventricle Assessment via Three-dimensional Anatomical Reconstruction (AVA-TAR): a computational toolkit for autonomous lateral ventricle assessment in preclinical hydrocephalus models.

bioRxiv : the preprint server for biology·2026
Same author

Undocking of an extensive ciliary network induces proteostasis and cell fate switching resulting in severe primary ciliary dyskinesia.

Science translational medicine·2025
Same author

The Heterotaxy Gene CCDC11 Is Important for Cytokinesis via RhoA Regulation.

Cytoskeleton (Hoboken, N.J.)·2024
Same author

Multiomics profiling of mouse polycystic kidney disease progression at a single-cell resolution.

Proceedings of the National Academy of Sciences of the United States of America·2024
Same author

Multi-omics profiling of mouse polycystic kidney disease progression at a single cell resolution.

bioRxiv : the preprint server for biology·2024
Same journal

Mechanosensing in immune cells: Implications for migration and beyond.

Current opinion in cell biology·2026
Same journal

Emerging role of organelles in cell migration.

Current opinion in cell biology·2026
Same journal

Nuclear adaptation in cell migration.

Current opinion in cell biology·2026
Same journal

Patterns in motion: Choreographing dynamic cell behaviours during tissue repair.

Current opinion in cell biology·2026
Same journal

Quo vadis reconstituted cell surfaces? Purpose and future perspectives for minimal systems of the cell plasma membrane.

Current opinion in cell biology·2026
Same journal

Nuclear determinants of mRNA and protein isoforms.

Current opinion in cell biology·2026
See all related articles

Related Experiment Video

Updated: Sep 7, 2025

Visualizing Multiciliated Cells in the Zebrafish Through a Combined Protocol of Whole Mount Fluorescent In Situ Hybridization and Immunofluorescence
09:33

Visualizing Multiciliated Cells in the Zebrafish Through a Combined Protocol of Whole Mount Fluorescent In Situ Hybridization and Immunofluorescence

Published on: November 18, 2017

8.3K

Development of a multiciliated cell.

Moe R Mahjoub1, Rashmi Nanjundappa2, Megan N Harvey2

  • 1Department of Medicine (Nephrology Division), Washington University, St Louis, MO, USA; Department of Cell Biology and Physiology, Washington University, St Louis, MO, USA.

Current Opinion in Cell Biology
|June 18, 2022
PubMed
Summary
This summary is machine-generated.

Multiciliated cells (MCCs) amplify centrioles to form hundreds of cilia for directional fluid propulsion. This review examines recent findings on how MCC progenitor cells regulate this precise number during differentiation.

More Related Videos

Mucociliary Epithelial Organoids from Xenopus Embryonic Cells: Generation, Culture and High-Resolution Live Imaging
07:44

Mucociliary Epithelial Organoids from Xenopus Embryonic Cells: Generation, Culture and High-Resolution Live Imaging

Published on: July 28, 2020

4.9K
Induced Differentiation of M Cell-like Cells in Human Stem Cell-derived Ileal Enteroid Monolayers
11:34

Induced Differentiation of M Cell-like Cells in Human Stem Cell-derived Ileal Enteroid Monolayers

Published on: July 26, 2019

8.7K

Related Experiment Videos

Last Updated: Sep 7, 2025

Visualizing Multiciliated Cells in the Zebrafish Through a Combined Protocol of Whole Mount Fluorescent In Situ Hybridization and Immunofluorescence
09:33

Visualizing Multiciliated Cells in the Zebrafish Through a Combined Protocol of Whole Mount Fluorescent In Situ Hybridization and Immunofluorescence

Published on: November 18, 2017

8.3K
Mucociliary Epithelial Organoids from Xenopus Embryonic Cells: Generation, Culture and High-Resolution Live Imaging
07:44

Mucociliary Epithelial Organoids from Xenopus Embryonic Cells: Generation, Culture and High-Resolution Live Imaging

Published on: July 28, 2020

4.9K
Induced Differentiation of M Cell-like Cells in Human Stem Cell-derived Ileal Enteroid Monolayers
11:34

Induced Differentiation of M Cell-like Cells in Human Stem Cell-derived Ileal Enteroid Monolayers

Published on: July 26, 2019

8.7K

Area of Science:

  • Cell Biology
  • Developmental Biology
  • Biophysics

Background:

  • Multiciliated cells (MCCs) are specialized cells with numerous motile cilia.
  • These cilia are essential for directional fluid transport in various tissues.
  • MCCs generate 30-500 basal bodies per cell through centriole amplification to template cilia.

Purpose of the Study:

  • To review recent findings on the mechanisms of centriole amplification in MCCs.
  • To address the question of how MCC progenitor cells regulate precise centriole and cilia numbers during differentiation.
  • To synthesize current knowledge on MCC fate determination, differentiation, and ciliogenesis.

Main Methods:

  • Review of recent studies utilizing mammalian cell culture, mice, and Xenopus models.
  • Analysis of research on centriole and cilia biogenesis pathways.
  • Examination of findings related to MCC differentiation and progenitor cell regulation.

Main Results:

  • Significant progress has been made in understanding MCC differentiation and ciliogenesis pathways.
  • Studies are beginning to uncover mechanisms of centriole and cilia biogenesis.
  • The precise regulation of centriole and cilia numbers by MCC progenitors remains an area needing further investigation.

Conclusions:

  • Understanding centriole amplification in MCCs is crucial for comprehending their specialized function.
  • Further research is needed to elucidate the regulatory mechanisms controlling centriole and cilia numbers during MCC differentiation.
  • This review consolidates current knowledge and highlights key questions in MCC biology.