A BOPHY based fluorescent probe for Hg²⁺via NTe₂ chelation

A BOPHY-based organotellurium-containing probe was synthesized and characterized via single crystal XRD for the selective and sensitive detection of Hg²⁺ over other metal ions. The probe detects Hg²⁺ in less than 1 s with a 2.5-fold enhancement in fluorescent intensity. Due to the chalcogenophilicity of mercury, Hg²⁺ was facilely trapped in the NTe₂ chelating cavity of the probe. The probe can detect Hg²⁺ in the nanomolar range (62 nM) and it showed reversibility with S^2- ions. The sensitivity of the probe for the detection of Hg²⁺ was confirmed in living HeLa cells.