Deranged Haemostasis: Rifampin-Induced Coagulopathy
Raghu Tiperneni1, Farhan Khalid1, Harshil Fichadiya1
1Monmouth Medical Center, Long Branch, NJ, USA.
Summary
Rifampin, an antibiotic, can rarely cause a supratherapeutic International Normalized Ratio (INR), a measure of blood clotting. This case highlights the importance of considering antibiotic-induced coagulopathy in patients with unexplained INR elevations.
Area of Science:
- Pharmacology
- Hematology
- Internal Medicine
Background:
- Prothrombin time (PT) and International Normalized Ratio (INR) are standard coagulopathy markers.
- Supratherapeutic INR is uncommon in patients not on vitamin K inhibitors and with normal liver function.
- Antibiotic-induced coagulopathy is an extremely rare complication.
Purpose of the Study:
- To report a unique case of supratherapeutic INR caused by rifampin.
- To emphasize the importance of recognizing antibiotic-induced coagulopathy.
Main Methods:
- Case report of an elderly male patient.
- Review of existing literature on rifampicin-induced coagulopathy.
Main Results:
- The patient presented with a supratherapeutic INR solely attributed to rifampin use.
- No other complications like disseminated intravascular coagulation were observed.
- Literature review confirmed the rarity of this specific complication.
Conclusions:
- Clinicians must consider antibiotic-induced coagulopathy, including bleeding or thromboembolic events.
- Early identification and discontinuation of the causative antibiotic are crucial for management.
- Awareness of drug side effects and interactions is essential.
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