Related Experiment Video
Updated: Sep 5, 2025
09:04
Analysis of Human T Cell Activity in an Allogeneic Co-Culture Setting of Pre-Treated Tumor Cells
Published on: March 7, 2025
655
Agonizing over the Stimulatory Immune Checkpoint ICOS
1Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, California.
Summary
Vopratelimab, an anti-inducible costimulator (ICOS) agonist, showed limited toxicity and modest clinical activity in a large trial. This immunotherapy approach may offer biomarkers for patient selection in cancer treatment.
Area of Science:
- Immunology
- Oncology
- Clinical Trials
Background:
- Vopratelimab is an agonist targeting the inducible costimulator (ICOS) pathway on T cells.
- A large phase I/II trial evaluated vopratelimab alone and in combination with nivolumab.
Discussion:
- The combination therapy demonstrated limited toxicity and modest clinical activity.
- Treatment with vopratelimab induced ICOS expression on CD4+ T cells.
Key Insights:
- ICOS expression on T cells could serve as a potential biomarker for patient selection.
- T-cell agonists represent a challenging but promising area in cancer immunotherapy.
Outlook:
- Further research is needed to optimize T-cell agonist therapies for cancer.
- Biomarker development is crucial for enhancing the efficacy of immunotherapies like vopratelimab.
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