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Mechanically and biologically enhanced 3D-printed HA/PLLA/dECM biocomposites for bone tissue engineering
Hanjun Hwangbo1, JiUn Lee1, GeunHyung Kim2
1Department of Biomechatronic Engineering, College of Biotechnology and Bioengineering, Sungkyunkwan University (SKKU), 16419 Suwon, South Korea.
International Journal of Biological Macromolecules
|July 14, 2022
Summary
Researchers enhanced hydroxyapatite (HA)/Poly (L-lactic acid) (PLLA) biocomposites for bone regeneration. Combining in situ plasma treatment during 3D printing with annealing and decellularized extracellular matrix (dECM) coating significantly improved mechanical and biological properties.
Area of Science:
- Biomaterials Science
- Tissue Engineering
- Regenerative Medicine
Background:
- Poly (L-lactic acid) (PLLA)-based biocomposites offer biocompatibility for tissue engineering.
- Limitations in mechanical and bioactive properties hinder their use in load-bearing bone defect applications.
Purpose of the Study:
- To develop mechanically and biologically enhanced hydroxyapatite (HA)/PLLA biocomposites.
- To improve scaffold suitability for bone tissue regeneration.
Main Methods:
- Fabrication of HA/PLLA biocomposites using 3D printing.
- In situ plasma treatment during 3D printing combined with thermal annealing.
- Coating with decellularized extracellular matrix (dECM) derived from porcine bones.
Main Results:
- The combined treatment increased the flexural modulus of the HA/PLLA composite by 2.1-fold.
- Efficient coating of the bioactive dECM material was achieved.
- In vitro studies demonstrated enhanced cell proliferation and osteogenic activity.
Conclusions:
- The HA/PLLA/dECM biocomposite scaffold exhibits improved mechanical strength and biological activity.
- This enhanced scaffold shows significant promise for bone tissue regeneration applications.
