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Related Concept Videos

Open Angle Glaucoma: Treatment01:27

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In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
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Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
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Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
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Related Experiment Video

Updated: Sep 4, 2025

Translaminar Autonomous System Model for the Modulation of Intraocular and Intracranial Pressure in Human Donor Posterior Segments
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The Strain Response to Intraocular Pressure Decrease in the Lamina Cribrosa of Patients with Glaucoma.

Cameron A Czerpak1, Michael Saheb Kashaf2, Brandon K Zimmerman1

  • 1Department of Mechanical Engineering, The Johns Hopkins University, Baltimore, Maryland.

Ophthalmology. Glaucoma
|July 21, 2022
PubMed
Summary
This summary is machine-generated.

Intraocular pressure reduction causes lamina cribrosa (LC) tissue to expand and contract, with shear strains being significant. Greater glaucoma damage correlates with more compliant biomechanical strains in the LC.

Keywords:
Digital volume correlationGlaucomaIntraocular pressureOptic nerve headStrain

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Area of Science:

  • Ophthalmology
  • Biomechanics
  • Medical Imaging

Background:

  • Glaucoma is a leading cause of irreversible blindness.
  • The lamina cribrosa (LC) is a critical optic nerve head structure affected in glaucoma.
  • Understanding biomechanical changes in the LC is crucial for glaucoma management.

Purpose of the Study:

  • To quantify biomechanical strains in the lamina cribrosa (LC) of human eyes following intraocular pressure (IOP) reduction.
  • To investigate the relationship between IOP changes and LC deformation.
  • To assess how glaucoma severity influences LC biomechanical properties.

Main Methods:

  • A cohort study involving glaucoma patients undergoing trabeculectomy surgery.
  • Noninvasive ocular imaging was performed before and after laser suturelysis to lower IOP.
  • Analysis focused on strains within the optic nerve head tissue and changes in LC depth.

Main Results:

  • IOP reduction led to LC expansion in thickness (anterior-posterior strain) and contraction in radius (radial strain).
  • Shear strains in the LC were substantial, nearly comparable to in-plane strains.
  • Greater IOP decrease correlated with increased tensile, maximum principal, and maximum shear strains.
  • LC biomechanical strain compliance was higher in eyes with more significant glaucoma damage, indicated by thinner retinal nerve fiber layers and poorer visual field indices.

Conclusions:

  • Intraocular pressure lowering induces significant biomechanical strains and dimensional changes in the LC.
  • Shear strains play a considerable role in LC deformation under reduced IOP.
  • The biomechanical response of the LC is altered in glaucoma, with increased compliance observed in eyes with more advanced disease.