Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Circulating 5-hydroxytryptamine concentrations in preterm newborns.

R E Schumacher, P M Farrell, E B Olson

    Pediatric Pulmonology
    |March 1, 1987
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    ECFS standards of care on CFTR-related disorders: Towards a comprehensive program for affected individuals.

    Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society·2024
    Same author

    Refining the continuum of CFTR-associated disorders in the era of newborn screening.

    Clinical genetics·2015
    Same author

    Improving the time efficiency of the Fourier synthesis method for slice selection in magnetic resonance imaging.

    Physica medica : PM : an international journal devoted to the applications of physics to medicine and biology : official journal of the Italian Association of Biomedical Physics (AIFB)·2015
    Same author

    Do prenatal steroids improve the survival of late preterm infants with complex congenital heart defects?

    Journal of neonatal-perinatal medicine·2014
    Same author

    Nursing care of the domiciliary patient in queensland.

    The Australian journal of physiotherapy·2014
    Same author

    CFTR mutation analysis and haplotype associations in CF patients.

    Molecular genetics and metabolism·2011
    Same journal

    Safety of Less Invasive Surfactant Administration in Preterm Infants: A Meta-Analysis.

    Pediatric pulmonology·2026
    Same journal

    Early Oxygenation Trajectory and Noninvasive Ventilation Failure in Non-Immunocompromised Children With Pediatric ARDS.

    Pediatric pulmonology·2026
    Same journal

    Pulmonary Exacerbations and Treatment in PCD: A Narrative Review.

    Pediatric pulmonology·2026
    Same journal

    Asthma in Children With Congenital Lung Malformations: A Population-Based Case-Control Study.

    Pediatric pulmonology·2026
    Same journal

    Long-Term Effect Of COVID-19 on Children's Lung Function: A Prospective Longitudinal Study.

    Pediatric pulmonology·2026
    Same journal

    Administrative Prevalence and Healthcare Utilization of Pediatric Cystic Fibrosis in a Middle-Income Country: A 10-Year Analysis of National Administrative Data.

    Pediatric pulmonology·2026
    See all related articles

    Circulating 5-hydroxytryptamine (5-HT) levels are low in preterm newborns and decrease significantly in the first week of life. Unlike adults, respiratory distress in newborns is not linked to elevated 5-HT.

    Area of Science:

    • Neonatal Physiology
    • Biochemistry
    • Respiratory Medicine

    Background:

    • Circulating 5-hydroxytryptamine (5-HT) alterations are implicated in adult respiratory failure.
    • Limited data exists on 5-HT concentrations in preterm newborns, especially concerning respiratory distress.

    Purpose of the Study:

    • To develop a sensitive micromethod for measuring free 5-HT in preterm infants.
    • To assess circulating free 5-HT concentrations in preterm newborns with and without respiratory distress.

    Main Methods:

    • Developed a micromethod using precolumn sample enhancement and ion exchange HPLC with electrochemical detection.
    • Analyzed 46 platelet-poor plasma samples from 29 preterm newborns (days 2-3 and 6-7 of life).
    • Assay detected minute 5-HT quantities (50 pg) from small blood volumes (0.2 ml).

    Related Experiment Videos

    Main Results:

    • Mean 5-HT concentrations were 1.77 ng/ml (days 2-3) and 0.69 ng/ml (days 6-7), showing a significant decline (P=0.01).
    • All 16 paired serial samples demonstrated a decrease in 5-HT over time (P=0.006).
    • Respiratory failure in newborns was not associated with increased free 5-HT, contrasting with adult findings.

    Conclusions:

    • Platelet-poor plasma 5-HT concentrations are low in preterm newborns.
    • A significant decline in 5-HT occurs within the first week of life in these infants.
    • Low neonatal 5-HT may indicate an enhanced pulmonary uptake capacity.