Autophagy Related Noncoding RNAs: Emerging Regulatory Factors of Gastric Cancer

Area of Science:

• Oncology
• Molecular Biology
• Genetics

Background:

• Gastric cancer (GC) is a prevalent malignancy with significant health impacts.
• Autophagy, a cellular degradation process, is integral to GC's occurrence, progression, drug resistance, and prognosis.
• Noncoding RNAs (ncRNAs), including miRNA, lncRNA, and circRNA, are increasingly recognized for their roles in GC pathogenesis.

Purpose of the Study:

• To summarize the current understanding of autophagy and autophagy-related ncRNAs in gastric cancer.
• To review the functions and research progress of these molecules in GC.
• To explore their potential applications in GC tumorigenesis, development, prognosis, and drug resistance.

Main Methods:

• Literature review and synthesis of existing research on autophagy and ncRNAs in GC.
• Focus on specific types of ncRNAs: miRNA, lncRNA, and circRNA.
• Analysis of their roles in GC progression and therapeutic resistance.

Main Results:

• Autophagy plays a multifaceted role in GC, influencing various stages of the disease.
• Autophagy-related ncRNAs (miRNA, lncRNA, circRNA) are significantly involved in GC development and progression.
• These ncRNAs demonstrate potential as biomarkers and therapeutic targets for GC.

Conclusions:

• Autophagy and ncRNAs are key players in gastric cancer, offering promising avenues for diagnosis and treatment.
• Further research into autophagy-related ncRNAs is essential for advancing GC clinical applications.
• Challenges and future research directions in this field were discussed.