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Evaluation of site-diversified, fully functionalized diazirine probes for chemical proteomic applications
Yan Tan1,2, Songsen Fu1,2, Tao Yang1,2
1Institute of Drug Discovery Technology, Ningbo University, Ningbo 315211, China. nifeng@nbu.edu.cn.
Chemical Communications (Cambridge, England)
|August 4, 2022
Abstract:
A series of site-diversified, fully functionalized diazirine probes are constructed based on a scaffold shared by several marketed EGFR-targeted drugs. The integrated analysis of protein targets of the site-diversified probe toolkit not only unveils more complete target space and helps suggest false positive targets, but also reveals dynamic events of multi-domain target-ligand interaction.
