Inhaled Corticosteroids Should Be Used in Infants and Preschoolers with Recurrent Wheezing

The infant or child presenting to the physician's office with persistent or recurrent wheezing during the first 2 years of life poses, often times, a diagnostic dilemma, and a therapeutic challenge. Until very recently, no guidelines were present to help the clinician navigate the very limited treatment options. The diagnosis of asthma in the very young is primarily difficult because of the lack of consistency of what is called asthma, and the failure to recognize the different phenotypes of asthma at different ages. Many classification and phenotypic descriptions have been proposed, but they continue to cause more confusion to already confused parents and perplexed physicians. Although these studies have provided much insight into the natural history of wheezy disorders, they have failed to affect clinical management to a large extent. Controversy persists as to when and why and how long inhaled corticosteroids (ICS) should be used in wheezy infants. Based on the current knowledge in this age group, ICS seems to be indicated in infants with multi-triggers wheeze, and in infants with a positive asthma predictive index. This article reviews the different phenotypic presentations of wheezy infant, the role and indications of ICS in this situation, and, finally, suggests a treatment plan based on the apparent cause of wheezing.