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Coronary Progenitor Cells and Soluble Biomarkers in Cardiovascular Prognosis after Coronary Angioplasty
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Investigating the inflammatory status in the patients candidate for second angiography after coronary stent

Sara Saffar Soflaei1, Maryam Saberi-Karimian2, Mojtaba Baktashian1

  • 1Department of Modern Sciences and Technologies, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.

Acta Cardiologica
|August 10, 2022
PubMed

Insights

This study found that 12 months after coronary artery disease (CAD) stent implantation, patients had lower high-sensitive C-reactive protein (hs-CRP) but altered inflammatory cytokine profiles. Medications may influence these changes despite increased pro- and anti-inflammatory factors.

Area of Science:

  • Cardiology
  • Immunology
  • Biochemistry

Background:

  • Atherosclerosis is characterized by inflammation.
  • Assessing inflammatory markers post-stent implantation is crucial for managing coronary artery disease (CAD).

Purpose of the Study:

  • To evaluate inflammatory cytokine and growth factor profiles in patients with established CAD 12 months after stent implantation.
  • To compare these profiles with patients undergoing their first angiography.

Main Methods:

  • Compared 193 patients with CAD post-stent (cases) to 107 CAD patients undergoing first angiography (controls).
  • Measured fasting blood glucose, lipids, hs-CRP, and serum concentrations of various cytokines (IL-1α, IL-1β, IL-2, IL-4, IL-6, IL-8, IL-10, TNF-α, IFN-γ, MCP-1) and growth factors (EGF, VEGF).

Main Results:

  • Cases had significantly lower fasting blood glucose, triglycerides, and hs-CRP levels than controls.
  • Significant differences were observed in cytokine and growth factor profiles between cases and controls.
  • Multivariate analysis revealed lower IL-2 and IL-4, but higher IL-8, TNF-α, MCP-1, EGF, and VEGF levels in cases post-stent implantation.

Conclusions:

  • Despite increased pro- and anti-inflammatory cytokines and growth factors, hs-CRP levels decreased one year after stent implantation in CAD patients.
  • This decrease in hs-CRP may be associated with higher medication use (statins, aspirin, glucose-lowering agents) to mitigate secondary event risk.
Abstract

Keywords:
Coronary artery diseaseanti-inflammatory cytokinesgrowth factorspro-inflammatory cytokines

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