Camphor and Menthol as Anticancer Agents: Synthesis, Structure-Activity Relationship and Interaction with Cancer Cell...

Area of Science:

• Natural product chemistry
• Medicinal chemistry
• Oncology

Background:

• Cancer, a disease of abnormal cell proliferation, affects many people globally.
• Current synthetic anticancer drugs often cause severe adverse effects.
• Natural compounds are being explored for their potential anticancer properties and lower toxicity.

Purpose of the Study:

• To review the synthesis of camphor and menthol derivatives.
• To investigate the in vitro anticancer activity of these derivatives.
• To explore their potential as ligands against various cancer cell lines.

Main Methods:

• Literature review of synthesis methods for camphor and menthol derivatives.
• In vitro evaluation of cytotoxic activity against cancer cell lines.
• Structure-activity relationship (SAR) studies.

Main Results:

• Camphor and menthol derivatives demonstrate significant cytotoxic activity.
• These derivatives show potential as targeted ligands for specific cancer cell lines.
• Structure-activity studies provide insights into their anticancer mechanisms.

Conclusions:

• Camphor and menthol derivatives are promising natural compounds with anticancer potential.
• These derivatives offer a viable alternative to synthetic anticancer agents due to reduced toxicity.
• Further research into their synthesis and SAR is warranted for drug development.