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Updated: Sep 1, 2025
08:55
Characterization of Multi-subunit Protein Complexes of Human MxA Using Non-denaturing Polyacrylamide Gel-electrophoresis
Published on: October 28, 2016
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MYC: a complex problem
Subhendu K Das1, Brian A Lewis1, David Levens1
1Gene Regulation Section, Laboratory of Pathology, Center for Cancer Research, National Cancer Institute (NCI), Bethesda, MD 20892-1500, USA.
Trends in Cell Biology
|August 13, 2022
Summary
The MYC protooncogene amplifies transcription but lacks a comprehensive model. This review proposes a
Area of Science:
- Molecular Biology
- Oncology
- Gene Regulation
Background:
- The MYC protooncogene is a key regulator of cellular processes, acting as a universal transcription amplifier.
- A complete model explaining MYC's complex interactions within transcription and replication machinery is currently lacking.
Purpose of the Study:
- To review MYC's role as an oncogenic driver and its regulation of gene-regulatory complexes.
- To propose a novel model for MYC's function and its energetic influence on transcription.
Main Methods:
- Literature review of MYC's function and interactions.
- Development of a conceptual 'hand-over model' for MYC trafficking.
- Analysis of MYC's energetic contribution to the transcription cycle.
Main Results:
- MYC interacts with a wide array of regulatory and effector complexes.
- A 'hand-over model' is proposed for the dynamic partitioning and trafficking of unstructured MYC.
- Unstructured MYC energetically facilitates efficient transcription cycle modulation.
Conclusions:
- MYC's multifaceted interactions require a dynamic model for understanding its function.
- The proposed 'hand-over model' offers new insights into MYC's regulatory mechanisms.
- MYC's energetic role in transcription is crucial for cellular processes and oncogenesis.
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