Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Two-generation chronic toxicity study with hexachlorobenzene in the rat.

D L Arnold, C A Moodie, B T Collins

    IARC Scientific Publications
    |January 1, 1986
    PubMed
    Summary

    Hexachlorobenzene (HCB) exposure in rats caused no effects on growth or survival but increased organ weights and reduced pup viability at high doses. Long-term exposure led to various tumors and organ damage in offspring.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Patterning Chronic Active Demyelination in Slowly Expanding/Evolving White Matter MS Lesions.

    AJNR. American journal of neuroradiology·2020
    Same author

    Comparison of Multiple Sclerosis Cortical Lesion Types Detected by Multicontrast 3T and 7T MRI.

    AJNR. American journal of neuroradiology·2019
    Same author

    Hidradenitis and smoking.

    The British journal of dermatology·2017
    Same author

    Manual Segmentation of MS Cortical Lesions Using MRI: A Comparison of 3 MRI Reading Protocols.

    AJNR. American journal of neuroradiology·2016
    Same author

    Diffusion tensor magnetic resonance imaging in very early onset pediatric multiple sclerosis.

    Multiple sclerosis (Houndmills, Basingstoke, England)·2015
    Same author

    Chromosomal ampC mutations in cefpodoxime-resistant, ESBL-negative uropathogenic Escherichia coli.

    British journal of biomedical science·2015

    Area of Science:

    • Toxicology
    • Environmental Health
    • Carcinogenesis

    Background:

    • Hexachlorobenzene (HCB) is a persistent organic pollutant with known toxic effects.
    • Understanding the long-term toxicological profile of HCB is crucial for risk assessment.

    Purpose of the Study:

    • To evaluate the toxicological effects of analytical grade hexachlorobenzene (HCB) through a two-generation feeding study in Sprague-Dawley rats.
    • To identify potential dose-dependent effects on reproduction, development, and long-term health outcomes.

    Main Methods:

    • Sprague-Dawley rats (F0 generation) were fed diets containing 0.0, 0.32, 1.6, 8.0, or 40.0 ppm HCB for 3 months before breeding.
    • F1 offspring were selected, weaned, and fed their parents' diet for lifetime exposure (130 weeks).
    • Evaluated parameters included growth, feed consumption, hematology, survival, fertility, pup viability, organ weights, and histopathology.

    Related Experiment Videos

    Main Results:

    • No treatment-related effects on growth, feed consumption, hematology, or survival were observed in either generation.
    • Increased heart and liver weights were noted in F0 males at 8.0 and 40.0 ppm HCB.
    • While fertility was unaffected, pup viability significantly decreased in the 40.0 ppm HCB group.
    • F1 generation exhibited increased incidences of parathyroid adenomas, phaeochromocytomas, liver nodules (females), liver chromogenesis, liver peliosis (females), liver lymphocytosis (males), and kidney nephrosis (males).

    Conclusions:

    • HCB exposure did not impact general health parameters like growth or survival but induced significant organ weight changes and reproductive toxicity (pup viability) at high doses.
    • Long-term HCB exposure in rats is associated with a range of histopathological changes and increased tumor incidence in multiple organs in the F1 generation.
    • These findings highlight the potential carcinogenic and organ-specific toxicities of HCB, emphasizing the need for continued monitoring and regulation of environmental HCB exposure.