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Environmental pharmacology-Dosing the environment: IUPHAR review 36
Christopher N Connolly1, Stephen P H Alexander2, Jamie A Davies3
1Independent.
British Journal of Pharmacology
|August 17, 2022
Summary
This study proposes applying pharmacology principles to environmental pesticide dosing. It introduces the
Area of Science:
- Environmental Science
- Pharmacology
- Toxicology
Background:
- Pesticide effects are mainly studied as toxicological outcomes.
- Sublethal and chronic pesticide exposure impacts on non-target species are understudied.
Purpose of the Study:
- To propose applying pharmacological principles to environmental pesticide risk assessment.
- To introduce the concept of an 'environmental therapeutic window' for safer pesticide use.
Main Methods:
- Applying standard pharmacological principles (e.g., dose-response, steady-state dose) to environmental contexts.
- Analogous to establishing safe clinical dosing regimens in humans.
Main Results:
- Pesticide risk assessment can be guided by an 'environmental therapeutic window'.
- This framework balances pest control efficacy with minimizing harm to beneficial organisms.
Conclusions:
- Pharmacological principles offer a robust framework for environmental pesticide risk assessment.
- A publicly accessible database of pesticide action data is needed for practical application.
Keywords:
agriculturebiodiversityenvironmentfungicideneonicotinoidpesticidepharmacologytherapeutic windowMore Related Videos
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