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Single-Molecule Fluorescence Visualization of DNA Polymerase Dynamics at G-Quadruplexes

Single-Molecule Fluorescence Visualization of DNA Polymerase Dynamics at G-Quadruplexes

Published on: April 4, 2025

Switchable and dynamic G-quadruplexes and their applications.

Jiantong Dong¹, Michael P O'Hagan¹, Itamar Willner¹

¹Institute of Chemistry, The Center for Nanoscience and Nanotechnology, The Hebrew University of Jerusalem, Jerusalem 91904, Israel. itamar.willner@mail.huji.ac.il.

Chemical Society Reviews

|August 17, 2022

Summary

This summary is machine-generated.

G-quadruplexes enable switchable DNA nanostructures and materials by dynamically reconfiguring. This review explores their use in DNA machines, catalysis, and stimuli-responsive nanomaterials for diverse applications.

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Area of Science:

Biochemistry and Molecular Biology
Materials Science
Nanotechnology

Background:

G-quadruplexes are increasingly recognized for their functional roles across biology, chemistry, and nanotechnology.
Their reversible dynamic reconfiguration is key to developing switchable DNA nanostructures and materials.

Purpose of the Study:

To review the switchable dynamic reconfiguration of G-quadruplexes as functional and structural motifs.
To highlight diverse applications in DNA nanotechnology and material science enabled by G-quadruplex dynamics.

Main Methods:

Discussion of G-quadruplex integration with enzymes for switchable catalysis.
Analysis of G-quadruplexes in constitutional dynamic and dissipative networks.
Exploration of G-quadruplexes in DNA nanostructures like origami tiles.
Examination of G-quadruplex assembly on surfaces for electrochemical devices and nanoparticle engineering.
Review of G-quadruplex functionalization of hydrogels and nanoparticle carriers for stimuli-responsive materials.

Main Results:

G-quadruplex dynamics are central to DNA switches, DNA machines, and supramolecular assemblies with switchable catalytic functions.
G-quadruplexes facilitate the creation of dynamic networks mimicking biological circuits.
Integration with nanostructures adds dynamic and mechanical features to static frameworks.
Surface-assembled G-quadruplexes enable electrochemical devices and switchable nanoparticle assemblies with tunable optical properties.
Functionalized nanomaterials exhibit stimuli-responsive behaviors like shape-memory and controlled drug release.

Conclusions:

G-quadruplexes are versatile building blocks for advanced DNA nanotechnology and material science.
Their dynamic reconfiguration offers significant potential for developing sophisticated devices and responsive materials.
Future developments are anticipated in areas like nanomedicine, driven by G-quadruplex-based innovations.