Evolving clinical challenges in uterus transplantation.

Area of Science:

• Reproductive Medicine
• Transplant Surgery
• Infertility Treatment

Background:

• Uterine factor infertility affects 1-2% of women, previously leaving childbearing impossible.
• Uterus transplantation (UTx) emerged in 2014, offering a potential solution.
• Current literature reports 64 UTx cases and 34 live births.

Purpose of the Study:

• To review the current state of uterus transplantation (UTx).
• To identify challenges hindering widespread clinical adoption.
• To propose solutions for overcoming these obstacles.

Main Methods:

• Literature review of reported uterus transplantation (UTx) cases and outcomes.
• Analysis of challenges in donor availability, recipient selection, surgical procedures, and post-transplant management.
• Synthesis of potential strategies to address identified limitations.

Main Results:

• Uterus transplantation has demonstrated successful live births.
• Significant challenges remain, including donor scarcity, surgical complexities, and recipient management.
• Ongoing research and clinical efforts are crucial for improving outcomes.

Conclusions:

• Uterus transplantation (UTx) is a promising but complex emerging technology.
• Addressing current limitations is key to establishing UTx in standard reproductive care.
• UTx could become a vital option for women with uterine factor infertility.