Progress in Intradermal and Transdermal Gene Therapy with Microneedles

Area of Science:

• Biomedical Engineering
• Dermatology
• Gene Therapy

Background:

• The skin's barrier function limits transdermal drug delivery, posing challenges for gene therapy effectiveness.
• Developing strategies to overcome skin permeability is crucial for treating various diseases with gene medicine.

Purpose of the Study:

• To review the advancements in microneedle-based transdermal gene therapy for skin-related disorders and immunity.
• To discuss current vectors and applications of microneedle gene therapy.

Main Methods:

• Review of recent literature on microneedle technology and gene therapy.
• Focus on microneedle-assisted transdermal delivery of nucleic acids and medicines.

Main Results:

• Microneedles offer a minimally invasive and painless approach to gene delivery through the stratum corneum.
• Significant progress has been made in applying microneedles for transdermal gene transfer and medication delivery.
• Microneedles facilitate effective delivery of gene medicines to target tissues, overcoming skin barrier limitations.

Conclusions:

• Microneedle transdermal gene therapy shows great promise for treating skin disorders and immune conditions.
• This technology represents a significant advancement in overcoming drug delivery challenges associated with the skin barrier.
• Further research into vectors and applications will expand the therapeutic potential of microneedle gene therapy.