A Fully Implantable Opto-Electro Closed-Loop Neural Interface for Motor Neuron Disease Studies

Area of Science:

• Biomedical Engineering
• Neuroscience
• Medical Devices

Background:

• Motor neuron disease research requires advanced tools for studying neural circuits in freely moving subjects.
• Current technologies often lack the necessary integration for chronic, in-vivo experimentation.

Purpose of the Study:

• To present a novel, fully implantable closed-loop device for investigating motor neuron disease treatments in rodents.
• To enable simultaneous neural recording and stimulation with high flexibility.

Main Methods:

• A 0.18 microm CMOS integrated circuit with 4 stimulators (16 channels each) for optical/electrical stimulation and a programmable front-end for neural recording.
• Wireless power delivery (>100 mW via Qi inductive link) and data telemetry (Bluetooth low energy).
• A backup rechargeable battery for sustained operation.

Main Results:

• The device supports arbitrary current waveforms (1.5 Hz to 50 kHz) and bandwidth-programmable neural recording.
• Wireless power transmission confirmed for freely moving rodents.
• The encapsulated implant measures 40 mm × 20 mm × 10 mm, with demonstrated electrical performance.

Conclusions:

• The developed implantable device offers a versatile platform for preclinical research in motor neuron disease.
• It facilitates advanced closed-loop neuromodulation studies in behaving animals.
• The system integrates wireless power, data telemetry, and flexible stimulation/recording capabilities.