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Updated: Aug 30, 2025

Author Spotlight: Decoding Mitochondrial Aging
Published on: June 30, 2023
Mitochondrial Dysregulation and the Influence in Neurodegenerative Diseases
Giuliana S Zuccoli1, Victor Corasolla Carregari2
1Laboratory of Neuroproteomics, Department of Biochemistry and Tissue Biology, Institute of Biology, University of Campinas (UNICAMP), Campinas, SP, Brazil. zuccoli.unicamp@gmail.com.
Abstract:
Mitochondrial function is essential to ensure vital cellular processes. Given the energy requirement of the brain, neuronal function, viability, and survival are closely related to proper mitochondrial function. Dysregulation of mitochondrial processes can lead to several detrimental effects in the cells and stablish the condition of mitochondrial dysfunction. This dysfunction is proposed to be greatly implicated in several neurodegenerative diseases, with evidence of compromised mitochondrial function and dynamics in Alzheimer's disease, Parkinson's disease, Huntington's disease, and amyotrophic lateral sclerosis.
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