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Necrosis

Necrosis

Necrosis is considered as an “accidental” or unexpected form of cell death that ends in cell lysis. The first noticeable mention of “necrosis” was in 1859 when Rudolf Virchow used this term to describe advanced tissue breakdown in his compilation titled “Cell Pathology”.
Morphological Manifestations of Necrosis
Necrotic cells show different types of morphological appearance depending on the type of tissue and infection. In coagulative necrosis, cells become...

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Updated: Aug 29, 2025

A Novel Human Epithelial Enteroid Model of Necrotizing Enterocolitis

A Novel Human Epithelial Enteroid Model of Necrotizing Enterocolitis

Published on: April 10, 2019

Necrotizing Enterocolitis in a Term Newborn: A Case Report.

Journal of Pediatric Health Care : Official Publication of National Association of Pediatric Nurse Associates & Practitioners

|September 4, 2022

Summary

This case report details a rare instance of necrotizing enterocolitis (NEC) in a full-term infant. It highlights NEC

Area of Science:

Neonatal Medicine
Pediatric Gastroenterology
Surgical Neonatology

Background:

Necrotizing enterocolitis (NEC) is a severe gastrointestinal emergency primarily affecting premature infants.
It involves inflammation and ischemic necrosis of the intestinal lining.
The exact cause of NEC remains unknown.

Purpose of the Study:

To present a case report of necrotizing enterocolitis (NEC) in a term infant.
To discuss the clinical presentation, diagnostic process, and management of NEC.
To review current literature on NEC in term neonates.

Main Methods:

Case report methodology.
Review of clinical presentation, diagnostic findings, and hospital course.
Literature search on necrotizing enterocolitis in term infants.

Keywords:

Necrotizing enterocolitis gastrointestinal emergency preterm newborn term newborn

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Last Updated: Aug 29, 2025

A Novel Human Epithelial Enteroid Model of Necrotizing Enterocolitis

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Published on: April 10, 2019

A Neonatal BALB/c Mouse Model of Necrotizing Enterocolitis

A Neonatal BALB/c Mouse Model of Necrotizing Enterocolitis

Published on: November 30, 2021

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Published on: June 8, 2022

Main Results:

A 5-day-old term infant presented with symptoms consistent with NEC.
The infant's clinical course, management, and follow-up were documented.
This case underscores NEC can occur outside of prematurity.

Conclusions:

Necrotizing enterocolitis (NEC) is a serious condition that can affect term infants, though rare.
Early recognition and management are crucial for improved outcomes.
Further research into NEC in term neonates is warranted.