Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Gene Regulation in Microbial Communities: Quorum Sensing01:28

Gene Regulation in Microbial Communities: Quorum Sensing

82
Quorum sensing is a mechanism of bacterial communication that enables coordinated gene expression in response to changes in population density. This facilitates collective behaviors that enhance survival, resource acquisition, and ecological adaptation. This process relies on small signaling molecules called autoinducers that accumulate as bacterial populations grow. When a critical threshold concentration of autoinducers is reached, bacterial cells collectively modify gene expression,...
82
Local Anesthetics: Adverse Effects01:12

Local Anesthetics: Adverse Effects

485
While local anesthetics are generally safe and well-tolerated, they can occasionally cause adverse effects that vary in severity. Local anesthetics can induce toxicity at two distinct levels. They can either produce local effects through direct contact with the neural elements or be absorbed into the bloodstream from the injection site, leading to systemic effects.
Once absorbed into the systemic circulation, local anesthetics can affect the organs that depend on the functioning of sodium...
485

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Rocaglamides from <i>Aglaia odorata</i> and nemoralisin-type diterpenoids from <i>Aglaia lawii</i>.

Natural product research·2026
Same author

Risk of Fetal Exposure to Teratogenic Medications: Development of Evidence for the Teratogenic Risk Impact and Mitigation (TRIM) Tool.

Drug safety·2026
Same author

Pain and treatment outcomes after initiating methadone vs buprenorphine among medicare patients with opioid use disorder and comorbid chronic pain: A target trial emulation.

PLoS medicine·2026
Same author

Identification of new grandifotane limonoids with <i>α</i>-glucosidase inhibitory activities from the bark of a Vietnamese <i>Swietenia</i> species.

Natural product research·2025
Same author

Teratogenic Risk Impact Mitigation (TRIM): Development of Explicit Criteria to Facilitate Decisions Regarding Teratogenic Risk Mitigation Strategies.

Drug safety·2025
Same author

Disparities in Initial Antihypertensive Intensity by Sex, Race and Ethnicity in Newly Treated Patients With Hypertension.

American journal of hypertension·2025
Same journal

Safety and Immunogenicity of the Live-Attenuated Quadrivalent Dengue Vaccine V181 Compared With Butantan-DV Among Healthy Adults in Brazil: A Randomized, Double-Blind, Phase 2 Trial.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America·2026
Same journal

Low Post-Treatment Recurrence After a Shortened All-oral Regimen for Pulmonary Rifampicin- or Multidrug-Resistant Tuberculosis in Individuals without Prior Second-Line Drug Exposure in Kazakhstan.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America·2026
Same journal

Sepsis Diagnostic Excellence and its Association with Mortality in Adults with Potential Infection.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America·2026
Same journal

10-Year Trends in Attributable and Contributable Mortality of Culture-Positive Invasive Aspergillosis in Patients with Hematologic Malignancies: Have We Reached the "Ceiling Efficacy Effect" of Modern Antifungals?

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America·2026
Same journal

Virologic Outcomes After LA ART Initiation with and without Viremia in Two Large U.S. Clinic Cohorts.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America·2026
Same journal

Andes Virus Exposure and Nosocomial Transmission Events to Healthcare Personnel: A Systematic Review.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America·2026
See all related articles

Related Experiment Video

Updated: Aug 29, 2025

Author Spotlight: Effectiveness of Extracorporeal Shockwave Therapy in Achilles Tendinopathy Treatment
03:50

Author Spotlight: Effectiveness of Extracorporeal Shockwave Therapy in Achilles Tendinopathy Treatment

Published on: August 2, 2024

1.3K

Quinolone Ear Drops and Achilles Tendon Rupture.

Phuong T Tran1,2, Patrick J Antonelli3,4, Almut G Winterstein1,3,5

  • 1Department of Pharmaceutical Outcomes and Policy, College of Pharmacy, University of Florida, Gainesville, Florida, USA.

Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America
|September 6, 2022
PubMed
Summary
This summary is machine-generated.

Otic quinolones (OQ) may increase the risk of Achilles tendon rupture and other tendon issues. Healthcare providers should discuss these potential systemic risks with patients.

Keywords:
adverse effectsotic quinoloneotitistendon rupture

More Related Videos

Author Spotlight: Integrating Mechanical and Biological Analysis in Tendinopathy Research
04:37

Author Spotlight: Integrating Mechanical and Biological Analysis in Tendinopathy Research

Published on: March 1, 2024

932
Using Q Suture to Enhance Resistance to Gap Formation and Tensile Strength of Repaired Flexor Tendons
10:32

Using Q Suture to Enhance Resistance to Gap Formation and Tensile Strength of Repaired Flexor Tendons

Published on: June 3, 2020

5.8K

Related Experiment Videos

Last Updated: Aug 29, 2025

Author Spotlight: Effectiveness of Extracorporeal Shockwave Therapy in Achilles Tendinopathy Treatment
03:50

Author Spotlight: Effectiveness of Extracorporeal Shockwave Therapy in Achilles Tendinopathy Treatment

Published on: August 2, 2024

1.3K
Author Spotlight: Integrating Mechanical and Biological Analysis in Tendinopathy Research
04:37

Author Spotlight: Integrating Mechanical and Biological Analysis in Tendinopathy Research

Published on: March 1, 2024

932
Using Q Suture to Enhance Resistance to Gap Formation and Tensile Strength of Repaired Flexor Tendons
10:32

Using Q Suture to Enhance Resistance to Gap Formation and Tensile Strength of Repaired Flexor Tendons

Published on: June 3, 2020

5.8K

Area of Science:

  • Pharmacovigilance
  • Otolaryngology
  • Orthopedics

Background:

  • Delayed eardrum healing in rats treated with otic quinolones (OQ) suggests potential systemic effects.
  • Case reports link OQ treatment to tendinopathies, raising concerns about adverse events.

Purpose of the Study:

  • To investigate the association between otic quinolone (OQ) exposure and tendon rupture outcomes.
  • To compare the risk of Achilles tendon rupture (ATR), Achilles tendinitis (AT), and all-type tendon rupture (ATTR) following OQ treatment versus other otitis treatments.

Main Methods:

  • A cohort study of 1,501,009 otitis episodes in patients aged 19-64.
  • Utilized an active comparator, new-user design with propensity score weighting to balance groups.
  • Follow-up included Achilles tendon rupture, tendinitis, and all tendon ruptures, with adjustments for potential confounders like physical activity.

Main Results:

  • Otic quinolone exposure was associated with a significantly increased hazard ratio for Achilles tendon rupture (HR, 4.49) and all-type tendon rupture (HR, 1.71).
  • Weighted risk differences indicated a higher incidence of ATR and ATTR per 100,000 episodes with OQ use.
  • Analysis of clavicle fractures and sports injuries suggested limited residual confounding from physical activity differences.

Conclusions:

  • Otic quinolone exposure may be linked to systemic adverse effects, including tendon injuries.
  • Clinicians should be aware of and counsel patients on the potential risks associated with OQ treatment.
  • Further research is warranted to elucidate the mechanisms and confirm these findings.