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Retinal Vascular Reactivity as Assessed by Optical Coherence Tomography Angiography
Published on: March 26, 2020
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Morphometrics in three dimensional choroidal vessel models constructed from swept-source optical coherence tomography
Yukinori Sugano1, Shunsuke Maeda1, Yutaka Kato1
1Department of Ophthalmology, Fukushima Medical University, Fukushima, Japan.
Scientific Reports
|September 6, 2022
Summary
Three-dimensional (3D) biomarkers derived from swept-source optical coherence tomography images reveal distinct choroidal vascular patterns. These 3D parameters offer new insights into age-related changes versus axial length elongation in choroidal vasculature.
Area of Science:
- Ophthalmology
- Medical Imaging
- Biomedical Engineering
Background:
- Choroidal vasculature plays a crucial role in ocular health.
- Understanding its structural changes is vital for diagnosing and managing eye diseases.
- Current imaging techniques provide limited 3D information about choroidal vessels.
Purpose of the Study:
- To develop and validate novel three-dimensional (3D) biomarkers for choroidal vasculature.
- To investigate the regional and age-related differences in choroidal structure using these 3D parameters.
- To differentiate the effects of aging from axial length elongation on choroidal vessels.
Main Methods:
- Creation of vessel volume, surface, and line models from swept-source optical coherence tomography (SS-OCT) images.
- Calculation of 3D biomarkers including choroidal volume (CVolume), surface area (VSurface), vessel length-associated index (VLI), choroidal vascularity index (CVI), and others.
- Application of cluster analysis to classify 3D parameters and assessment of regional distribution (fovea vs. parafovea).
Main Results:
- Cluster analysis identified two main groups of parameters related to vessel volume and vessel length-to-stromal ratio.
- Higher values for several 3D parameters (VVolume, CVolume, VSurface, CVI, VLI, VL-S ratio, VDI) were observed in the foveal center compared to the parafovea.
- While vessel volume decreased with age and axial length elongation, specific parameters like VLI, VLDI, VL-S ratio, and CVI decreased with age but not axial length elongation.
Conclusions:
- The study successfully generated and utilized novel 3D biomarkers from SS-OCT for choroidal vasculature analysis.
- Distinct structural differences in choroidal vessel volume reduction were observed between aging and axial length elongation.
- These 3D parameters hold potential for providing enhanced, quantitative information about choroidal vascular health and disease.
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