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Abnormal Proliferation

Abnormal Proliferation

Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...

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Updated: Aug 29, 2025

Yeast As a Chassis for Developing Functional Assays to Study Human P53

Yeast As a Chassis for Developing Functional Assays to Study Human P53

Published on: August 4, 2019

P53 Suppressor Gene Tissue Microarray-based Protein Expression Analysis in Meningiomas.

Dimitrios Roukas¹, Anastasios Kouzoupis², Despoina Spyropoulou³

¹Department of Psychiatry, 417 VA (NIMTS) Hospital, Athens, Greece.

In Vivo (Athens, Greece)

|September 13, 2022

Summary

This summary is machine-generated.

p53 overexpression is common in meningiomas, a type of brain tumor. High p53 levels correlate with aggressive tumor behavior and higher recurrence rates, particularly in atypical and anaplastic subtypes.

Keywords:

Meningioma immunohistochemistry p53 suppressor genes tissue microarrays

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Published on: February 28, 2019

Area of Science:

Neuro-oncology
Molecular pathology
Cancer genetics

Background:

Meningiomas are the most common primary intracranial CNS tumors in adults.
Tumorigenesis involves oncogene over-activation and tumor suppressor gene silencing.
The role of p53 suppressor gene expression in meningioma behavior requires further investigation.

Purpose of the Study:

To investigate the impact of p53 suppressor gene expression on meningioma clinic-pathological features.
To analyze p53 protein expression levels in various meningioma subtypes.
To correlate p53 expression with tumor aggressiveness and mitotic activity.

Main Methods:

Immunohistochemistry assay on tissue microarray cores from 50 meningiomas.
Digital image analysis for quantitative assessment of p53 protein expression.
Inclusion of a diverse range of histopathological subtypes.

Main Results:

p53 protein overexpression (high staining) observed in 54% of cases (27/50).
p53 overexpression significantly correlated with increased mitotic index (p=0.001).
Atypical and anaplastic meningiomas showed the highest p53 expression rates (p=0.001).

Conclusions:

p53 overexpression is prevalent across various meningioma subtypes.
High p53 expression is linked to aggressive biological behavior and increased mitotic rates.
Elevated p53 levels are particularly associated with aggressive atypical/anaplastic meningiomas and their high recurrence rates.