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Presumably Corneal Graft Rejection after COVID-19 Vaccination
Maryam Mohammadzadeh1, Sadid Hooshmandi2, Mina Jafari2
1Translational Ophthalmology Research Center, Farabi Eye Hospital, Tehran University of Medical Sciences, Tehran, Iran.
Case Reports in Ophthalmology
|September 26, 2022
Summary
Two patients experienced corneal graft rejection after receiving the Sinopharm COVID-19 vaccine. This highlights potential adverse reactions and the need for vigilant post-vaccination monitoring in transplant recipients.
Area of Science:
- Ophthalmology
- Immunology
- Vaccinology
Background:
- Corneal transplantation is a common procedure to restore vision.
- Immunosuppression is crucial for graft survival.
- COVID-19 vaccination is recommended for all eligible individuals.
Observation:
- Two patients with prior corneal transplants developed graft rejection within a week of receiving the Sinopharm COVID-19 vaccine.
- Symptoms included unilateral corneal graft rejection signs.
- Both cases were successfully treated with topical steroids.
Findings:
- This is the first report of corneal graft rejection following the Sinopharm COVID-19 vaccine.
- Rejection occurred shortly after vaccination.
- Potential mechanisms include allogenic reaction or adjuvant effects, though herpes simplex keratitis reactivation was considered in one case.
Implications:
- Ophthalmologists must consider corneal graft rejection as a potential adverse event post-COVID-19 vaccination.
- Close monitoring of graft health after immunization is essential.
- Patients should be educated on rejection signs and the importance of prompt medical attention.
