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Adenoid Ameloblastoma Versus Dentinogenic Ghost Cell Tumor
Victor Coutinho Bastos1, Carolina Cavaliéri Gomes1, Ricardo Santiago Gomez2
1Department of Pathology, Biological Science Institute (ICB), Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, Brazil.
Head and Neck Pathology
|September 28, 2022
Summary
Dentitinogenic ghost cell tumors may be misdiagnosed. Some cases previously classified as dentinogenic ghost cell tumors might be better identified as adenoid ameloblastoma, especially those with duct-like structures.
Area of Science:
- Oral pathology
- Head and neck oncology
- Tumor diagnosis
Background:
- A systematic review identified duct-like/cribriform architecture in 3.8% of dentinogenic ghost cell tumors.
- This finding necessitates a discussion on the differential diagnosis between dentinogenic ghost cell tumor and adenoid ameloblastoma.
Approach:
- A critical review of microscopic findings from a recent publication in Head and Neck Pathology was conducted.
- The study focused on differentiating features between dentinogenic ghost cell tumor and adenoid ameloblastoma.
Key Points:
- Adenoid ameloblastoma is characterized by duct-like structures and whorls/morules.
- These features overlap with dentinogenic ghost cell tumors, leading to potential diagnostic confusion.
- Some cases diagnosed as dentinogenic ghost cell tumors may be reclassified as adenoid ameloblastoma.
Conclusions:
- Reassessment of dentinogenic ghost cell tumor cases is recommended.
- Diagnostic criteria from the 2022 WHO classification of Head and Neck Tumors should be applied.
- Accurate classification is crucial for appropriate patient management.
Keywords:
CTNNB1 mutationsadenoid ameloblastomadentinogenic ghost cell tumordiagnosisghost cell lesions
