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Updated: Aug 26, 2025

Diagnosis of Hirschsprung's Disease by Immunostaining Rectal Suction Biopsies for Calretinin, S100 Protein and Protein Gene Product 9.5
Published on: April 26, 2019
Management of Anorectal Malformations and Hirschsprung Disease
Colin D Gause1, Sanjay Krishnaswami2
1Department of Surgery, Division of Pediatric Surgery, Providence Health & Services, 9427 Southwest Barnes Road, Clinic Office Suite 395, Portland, OR 97225, USA.
Abstract:
Anorectal malformations (ARM) and Hirschsprung disease (HD) are managed with placement of normal intestine within the anal sphincter complex. Long-term complications specific to ARM include fistula remnants, recurrence, urinary reflux with associated chronic renal insufficiency, sexual dysfunction, and fertility difficulties. Complications specific to HD include enterocolitis, persistent or acquired aganglionosis, and internal sphincter achalasia. ARM and HD patients are both at risk of stricture, bowel dysfunction and incontinence, which can have a severe impact on quality of life. Bowel management strategies should be tailored to the patient's specific category of bowel dysfunction.
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