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Polypharmacy in Oncology.

Justin J Cheng1, Asal M Azizoddin2, Michael J Maranzano2

  • 1Department of Medicine, Wake Forest University School of Medicine, 1 Medical Center Boulevard, Winston-Salem, NC 27101, USA.

Clinics in Geriatric Medicine
|October 9, 2022
PubMed
Summary
This summary is machine-generated.

Polypharmacy, or taking five or more medications, negatively impacts older cancer patients. Careful medication review and interventions are crucial for improving quality of life and survival in these patients.

Keywords:
Breast cancerChronic lymphocytic leukemiaColon cancerGeriatricsLung cancerPolypharmacyProstate cancer

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Area of Science:

  • Geriatric Medicine
  • Oncology
  • Clinical Pharmacology

Background:

  • Polypharmacy (five or more medications) is a common geriatric syndrome.
  • It is particularly prevalent in older adults diagnosed with cancer.
  • This condition poses significant risks for patients with breast, lung, prostate, colorectal cancer, and chronic lymphocytic leukemia.

Purpose of the Study:

  • To highlight the adverse effects of polypharmacy in older cancer patients.
  • To examine the impact of polypharmacy on drug interactions and cancer treatment efficacy.
  • To underscore the association between polypharmacy and patient survival outcomes.

Main Methods:

  • Literature review on polypharmacy in geriatric oncology.
  • Analysis of adverse effects, drug-drug interactions, and treatment efficacy.
  • Examination of survival data in relation to polypharmacy.

Main Results:

  • Polypharmacy leads to adverse effects and interactions with comorbid medications.
  • It can reduce the efficacy of systemic cancer therapies.
  • Polypharmacy is linked to worse progression-free and overall survival in lung and colorectal cancers.

Conclusions:

  • Judicious medication review is essential for older cancer patients experiencing polypharmacy.
  • Interventions targeting polypharmacy can improve quality of life.
  • Addressing polypharmacy may enhance survival outcomes in this vulnerable population.