Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Classification of Illness01:17

Classification of Illness

7.8K
The meaning of illness is individualized to each person who experiences an alteration in health. In contrast, disease is a medical term indicating a pathological change in the structure and function of the body or mind. It is a condition that has specific symptoms and boundaries.
An illness is a response to a disease in which the person's level of functioning is changed compared with a previous level. The general classification of illness includes acute and chronic.
Acute illness is severe...
7.8K
Sleepwalking and Sleep Talking01:17

Sleepwalking and Sleep Talking

273
Somnambulism, commonly known as sleepwalking, involves individuals engaging in activities ranging from simple walking to more complex behaviors such as driving. Sleepwalking typically occurs during the slow-wave sleep stages 3 and 4 early in the night when the person is not dreaming, contradicting the myth that sleepwalkers are acting out their dreams.
Factors that increase the likelihood of sleepwalking include sleep deprivation and alcohol consumption. Contrary to common beliefs, it is safe...
273
Cognitive Dissonance01:38

Cognitive Dissonance

33.1K
Social psychologists have documented that feeling good about ourselves and maintaining positive self-esteem is a powerful motivator of human behavior (Tavris & Aronson, 2008). In the United States, members of the predominant culture typically think very highly of themselves and view themselves as good people who are above average on many desirable traits (Ehrlinger, Gilovich, & Ross, 2005). Often, our behavior, attitudes, and beliefs are affected when we experience a threat to our...
33.1K
Sleep-Wake Cycles01:24

Sleep-Wake Cycles

1.5K
Sleep is an essential physiological process vital to maintaining overall well-being. The reticular activating system (RAS), a network of neurons in the brainstem, regulates wakefulness and sleep. While it may seem passive, sleep consists of distinct cycles, each with its unique characteristics and functions. Two key sleep phases are non-rapid eye movement (NREM) and  rapid eye movement (REM).
NREM Sleep
NREM sleep comprises four progressive stages that seamlessly merge:
1.5K
Restarting Stalled Replication Forks02:37

Restarting Stalled Replication Forks

2.0K
2.0K
Psychosexual Stages of Personality: Latency01:16

Psychosexual Stages of Personality: Latency

609
Following the phallic stage in Freud's theory of psychosexual development, children enter a phase called the latency period, which lasts from approximately six to twelve years of age. Unlike earlier stages, where sexual impulses played a central role, Freud believed these impulses are repressed during the latency period, becoming part of the unconscious. This stage is often described as a time of psychological calm after the turbulence of the phallic stage.
The latency period is not...
609

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[Dormancy: There and Back Again].

Molekuliarnaia biologiia·2022
Same author

To the Academician Alexander Spirin 90th Anniversary from Informosomes to the World of mRNP.

Doklady. Biochemistry and biophysics·2021
Same author

[Plant Stem Cells].

Molekuliarnaia biologiia·2020
Same author

[Neural Crest-An Unusual Population of Embryonic Cells].

Molekuliarnaia biologiia·2019
Same author

Regulation of Zygotic Genome and Cellular Pluripotency.

Biochemistry. Biokhimiia·2016
Same author

[Cement gland as the adhesion organ in Xenopus laevis embryos].

Ontogenez·2012

Related Experiment Video

Updated: Aug 26, 2025

Resurrection of Dormant Daphnia magna: Protocol and Applications
07:37

Resurrection of Dormant Daphnia magna: Protocol and Applications

Published on: January 19, 2018

18.5K

Dormancy: There and Back Again.

E S Pshennikova1, A S Voronina1

  • 1Bakh Institute of Biochemistry, Federal Research Center of Biotechnology, Russian Academy of Sciences, 119071 Moscow, Russia.

Molecular Biology
|October 11, 2022
PubMed
Summary

Cell dormancy allows survival in harsh conditions for normal cells and pathogens like tuberculosis bacilli and cancer cells. Pathogens and cancer cells can manipulate their microenvironment to control dormancy and evade therapies.

Keywords:
Mycobacterium tuberculosisdormancymesenchymal stem cellsmetastasismetastatic nichestumor cells

More Related Videos

An In Vitro System to Study Tumor Dormancy and the Switch to Metastatic Growth
09:14

An In Vitro System to Study Tumor Dormancy and the Switch to Metastatic Growth

Published on: August 11, 2011

16.0K
An In Vitro Dormancy Model of Estrogen-sensitive Breast Cancer in the Bone Marrow: A Tool for Molecular Mechanism Studies and Hypothesis Generation
08:48

An In Vitro Dormancy Model of Estrogen-sensitive Breast Cancer in the Bone Marrow: A Tool for Molecular Mechanism Studies and Hypothesis Generation

Published on: June 30, 2015

8.3K

Related Experiment Videos

Last Updated: Aug 26, 2025

Resurrection of Dormant Daphnia magna: Protocol and Applications
07:37

Resurrection of Dormant Daphnia magna: Protocol and Applications

Published on: January 19, 2018

18.5K
An In Vitro System to Study Tumor Dormancy and the Switch to Metastatic Growth
09:14

An In Vitro System to Study Tumor Dormancy and the Switch to Metastatic Growth

Published on: August 11, 2011

16.0K
An In Vitro Dormancy Model of Estrogen-sensitive Breast Cancer in the Bone Marrow: A Tool for Molecular Mechanism Studies and Hypothesis Generation
08:48

An In Vitro Dormancy Model of Estrogen-sensitive Breast Cancer in the Bone Marrow: A Tool for Molecular Mechanism Studies and Hypothesis Generation

Published on: June 30, 2015

8.3K

Area of Science:

  • Cell biology
  • Pathology
  • Microbiology

Background:

  • Many cell types, including stem cells and microorganisms, can enter a dormant state to survive unfavorable conditions.
  • Pathological cells like tuberculosis bacilli and cancer cells also exhibit dormancy, leading to latent infections and secondary tumors.
  • Dormant cells are resistant to conventional therapies and host immune responses.

Purpose of the Study:

  • To review the regulatory mechanisms of cell dormancy.
  • To explore how microenvironmental factors trigger entry and exit from dormancy.
  • To highlight the differences in dormancy regulation between normal and pathological cells.

Main Methods:

  • Review of existing literature on cell dormancy.
  • Analysis of regulatory factors and signaling pathways involved in dormancy.
  • Comparison of dormancy mechanisms in normal, microbial, and cancerous cells.

Main Results:

  • Cell dormancy is regulated by a balance of 'forbidding' and 'permitting' signals from the microenvironment.
  • Pathogens and cancer cells possess unique abilities to alter their microenvironment, influencing their own dormancy and survival.
  • Understanding these mechanisms is crucial for developing targeted therapies.

Conclusions:

  • Cell dormancy is a critical survival strategy with implications in both normal physiology and disease.
  • Pathological dormancy presents therapeutic challenges due to resistance mechanisms.
  • Further research into microenvironmental regulation of dormancy could yield novel treatment strategies.