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Mannobioside biomimetics that trigger DC-SIGN binding selectivity
Irene Herrera-González1, Michel Thépaut2, Elena M Sánchez-Fernández1
1Department of Organic Chemistry, Faculty of Chemistry, University of Seville, C/Profesor García González 1, Seville 41012, Spain. mellet@us.es.
Abstract:
Selective DC-SIGN targeting vs. langerin might lead to anti-infective agents, given their counteracting effects upon infection by some pathogens. Here we show that multivalent sp2-iminosugar-containing mannobioside analogs can achieve total DC-SIGN selectivity by levering the canonic binding mode towards high-mannose oligosaccharide ligands, behaving as factual biomimics.
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