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Updated: Aug 24, 2025

Mapping Bacterial Functional Networks and Pathways in Escherichia Coli using Synthetic Genetic Arrays
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Published on: November 12, 2012

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Refactored genetic codes enable bidirectional genetic isolation

Jérôme F Zürcher1, Wesley E Robertson1, Tomás Kappes2

  • 1Medical Research Council Laboratory of Molecular Biology, Cambridge, UK.

Science (New York, N.Y.)
|October 20, 2022
PubMed
Summary

Researchers engineered synthetic genetic codes in *Escherichia coli* to prevent the spread of artificial DNA. This innovation creates orthogonal genetic codes and gene transfer systems, enhancing biosecurity against mobile genetic elements like viruses.

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