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Updated: Aug 24, 2025

A Platform of Anti-biofilm Assays Suited to the Exploration of Natural Compound Libraries
Published on: December 27, 2016
Antibacterial effects of natural compounds on biofilm formation of Streptococcus mutans
Farideh Kamarehei1, Mohsen Mehdiabadi2, Fariba Naderi2
1Department of Microbiology, Faculty of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran.
Abstract:
Streptococcus mutans is the main cariogenic pathogen in the oral cavity, considered to contribute toward oral diseases. S. mutans is predominantly entrapped in plaque biofilms.
Objectives:
In this study, we surveyed the antibacterial activity of natural compounds in terms of the biofilm production of S. mutans.
Material And Methods:
We extracted the studies related to natural compounds affected on S. mutans biofilm from different databases.
Results:
Disruption of S. mutans viability in biofilms by a potent new pharmacological factor could inhibit and remove cavities. Various antibacterial agents are needed to destroy biofilms that remove both pathogens and commensal bacteria, and also exert inhibitory effects on many bacterial species.
Conclusions:
An effective therapeutic agent for dental caries has to be capable of removing pathogens and their biofilms. Specific virulence attributes of S. mutans exist; hence, natural compounds that have excellent properties to combat such pathogens need to be selected.
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