Gender differences in chronic total occlusion percutaneous coronary interventions: Insights from the PROGRESS-CTO...

Area of Science:

• Cardiology
• Interventional Cardiology
• Health Services Research

Background:

• Limited data exist on gender-specific outcomes for chronic total occlusion (CTO) percutaneous coronary interventions (PCI).
• Understanding these differences is crucial for optimizing patient care and procedural strategies.

Purpose of the Study:

• To compare baseline characteristics, procedural details, and outcomes between men and women undergoing CTO PCI.
• To identify potential gender-based disparities in CTO PCI.
• To inform clinical decision-making and improve patient management.

Main Methods:

• A retrospective analysis of 9457 CTO PCIs performed at 38 centers from 2012 to 2022.
• Comparison of clinical and angiographic data, procedural techniques, and in-hospital outcomes between male and female patients.
• Statistical analysis to determine significant differences.

Main Results:

• Women (19%) were older, had more comorbidities, and higher left ventricular ejection fraction than men (81%).
• Women showed higher technical (89% vs. 86%) and procedural (87% vs. 84%) success rates.
• Women experienced higher in-hospital major adverse cardiovascular events (MACE) (2.9% vs. 1.8%) compared to men.

Conclusions:

• Women undergoing CTO PCI achieve higher technical and procedural success rates.
• Despite higher success, women face an increased risk of in-hospital MACE.
• Gender-specific considerations are important in the management of CTO PCI.