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A First Suspected Case of Fibrosing Mediastinitis After Anti-PD-1 Therapy
Carolyn J Park1, Sujethra Vasu1, Jean L Urbain2
1Department of Internal Medicine, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA.
JACC. Case Reports
|October 27, 2022
Abstract:
We describe a first suspected case of fibrosing mediastinitis following anti-programmed death (PD)-1 therapy, pembrolizumab. Multimodality imaging, including cardiac magnetic resonance imaging, and a multidisciplinary team approach were integral to the diagnosis. If further substantiated, systematic surveillance after anti-PD-1 therapy for fibrosing mediastinitis may be warranted. (Level of Difficulty: Intermediate.).
Keywords:
CHF, congestive heart failureCMR, cardiac magnetic resonanceFDG, fluorodeoxyglucoseLGE, late gadolinium enhancementPD-1, programmed death-1PET, positron emission tomographyanti–programmed death-1cardiac magnetic resonancefibrosing mediastinitisfibrosisimmunotherapypositron emission tomography
