CLINICAL AND FUNCTIONAL STATE OF THE THYROID GLAND IN WOMEN OF PERI- AND POSTMENOPAUSAL AGE WITH METABOLIC SYNDROME

The article deals with the problem of the clinical and functional relationship between the state of the thyroid gland in women of menopausal age and the components of the metabolic syndrome (MS). The purpose of the study: to assess the relationship between thyroid dysfunction and various components of MS in women of peri- and postmenopausal age. 80 menopausal women (mean age 55 years) were examined, of which 40 people with MS constituted the main group, and the comparison group - a similar number of women without MS. The inclusion criterion in the study was the presence of signs of abdominal obesity (AO) according to the WHO criteria (2008). Anthropometric, functional (BP), laboratory (lipidogram, TSH, freeT4, antibodies to TPO, FSH, LH, urinary iodine concentration) and instrumental (ultrasound of the thyroid gland) data, statistical analysis using the program SPSSStatistics version 20 were evaluated. The women were divided into two age groups: group 1 - perimenopausal and group 2 - postmenopausal. There were 40 people in each group (20 women with MS and 20 women without MS). It has been shown that peri- and postmenopausal women with MS have subclinical hypothyroidism. The influence of peripheral blood TSH levels in peri- and postmenopausal women with MS on body weight, carbohydrate and lipid metabolism, and sex hormones was established.